Title:
HETERODIMER COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS
Document Type and Number:
WIPO Patent Application WO/2021/220061
Kind Code:
A3
Abstract:
Described herein are processable compositions comprising at least one moiety that is processable in its free form. Also described herein are compositions and methods for the treatment of ocular diseases or disorders including glaucoma, blepharitis, ocular inflammation, diabetic macular edema, posterior inflammation, anterior inflammation, macular degeneration (e.g., wet macular degeneration (AMD) or dry AMD), post-cataract surgery, and retinal vein occlusion. Said compositions and methods comprise steroids and prostaglandins which demonstrate anti-inflammatory activity, intraocular pressure (IOP) lowering, and/or other desirable activities. Injection of said compositions in the eye provides therapeutic benefit to patients suffering from ocular disorders.
Inventors:
PARRAG IAN (CA)
NAIMARK WENDY (CA)
STATHAM MATTHEW ALEXANDER JOHN (CA)
RIZIS GEORGIOS (CA)
BATTISTON KYLE (CA)
NAIMARK WENDY (CA)
STATHAM MATTHEW ALEXANDER JOHN (CA)
RIZIS GEORGIOS (CA)
BATTISTON KYLE (CA)
Application Number:
PCT/IB2021/000332
Publication Date:
December 23, 2021
Filing Date:
April 29, 2021
Export Citation:
Assignee:
RIPPLE THERAPEUTICS CORP (CA)
International Classes:
C07J5/00; A61K9/00; A61K31/557; A61K31/56; C07J75/00
Domestic Patent References:
| WO2007056457A2 | 2007-05-18 |
Foreign References:
| US4198405A | 1980-04-15 | |||
| US4318908A | 1982-03-09 | |||
| JPS50123654A | 1975-09-29 | |||
| US20170028078A1 | 2017-02-02 | |||
| US9604949B2 | 2017-03-28 |
Other References:
DAO KINH-LUAN, HANSON ROBERT N.: "Targeting the Estrogen Receptor using Steroid -Therapeutic Drug Conjugates (Hybrids)", BIOCONJUGATE CHEMISTRY, vol. 23, no. 11, 5 October 2012 (2012-10-05), pages 2139 - 2158, XP055888144, ISSN: 1043-1802, Retrieved from the Internet
JURČEK ONDŘEJ, IKONEN SATU, BUŘIČOVÁ LUCIE, WIMMEROVÁ MARTINA, WIMMER ZDENĚK, DRAŠAR PAVEL, HORNÍČEK JAN, GALANDÁKOVÁ ADÉLA, ULRIC: "Succinobucol’s New Coat — Conjugation with Steroids to Alter Its Drug Effect and Bioavailability", MOLECULES, vol. 16, no. 11, 10 November 2011 (2011-11-10), pages 9404 - 9420, XP055888147, DOI: 10.3390/molecules16119404
NAVACCHIA MARIA LUISA, MARCHESI ELENA, PERRONE DANIELA: "Bile Acid Conjugates with Anticancer Activity: Most Recent Research", MOLECULES, vol. 26, no. 1, 1 January 2021 (2021-01-01), pages 25, XP055888150, DOI: 10.3390/molecules26010025
JURČEK ONDŘEJ, IKONEN SATU, BUŘIČOVÁ LUCIE, WIMMEROVÁ MARTINA, WIMMER ZDENĚK, DRAŠAR PAVEL, HORNÍČEK JAN, GALANDÁKOVÁ ADÉLA, ULRIC: "Succinobucol’s New Coat — Conjugation with Steroids to Alter Its Drug Effect and Bioavailability", MOLECULES, vol. 16, no. 11, 10 November 2011 (2011-11-10), pages 9404 - 9420, XP055888147, DOI: 10.3390/molecules16119404
NAVACCHIA MARIA LUISA, MARCHESI ELENA, PERRONE DANIELA: "Bile Acid Conjugates with Anticancer Activity: Most Recent Research", MOLECULES, vol. 26, no. 1, 1 January 2021 (2021-01-01), pages 25, XP055888150, DOI: 10.3390/molecules26010025
Download PDF: