Title:
HETERODIMER FC POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2022/044248
Kind Code:
A1
Abstract:
A non-limiting embodiment of the current invention provides: a polypeptide including a mutant Fc region that includes an amino acid modification in a parent Fc region; and a production method for said polypeptide.
Inventors:
KATADA HITOSHI (JP)
TATSUMI KANAKO (JP)
TATSUMI KANAKO (JP)
Application Number:
PCT/JP2020/032547
Publication Date:
March 03, 2022
Filing Date:
August 28, 2020
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N15/13; C07K16/46
Domestic Patent References:
| WO2013002362A1 | 2013-01-03 | |||
| WO2014104165A1 | 2014-07-03 |
Foreign References:
| JP2014504265A | 2014-02-20 | |||
| JP2014509857A | 2014-04-24 |
Other References:
ESCOBAR-CABRERA, ERIC ET AL.: "Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function", ANTIBODIES, vol. 6, no. 2, 7, 16 May 2017 (2017-05-16), pages 1 - 16, XP055483933, DOI: 10.3390/antib6020007
LIU, ZHI ET AL.: "Asymmetrical Fc Engineering Greatly Enhances Antibody- dependent Cellular Cytotoxicity (ADCC) Effector Function and Stability of the Modified Antibodies", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 6, 5 December 2013 (2013-12-05), pages 3571 - 3590, XP055170896, DOI: 10.1074/jbc.M113.513366
LIU, ZHI ET AL.: "Asymmetrical Fc Engineering Greatly Enhances Antibody- dependent Cellular Cytotoxicity (ADCC) Effector Function and Stability of the Modified Antibodies", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 6, 5 December 2013 (2013-12-05), pages 3571 - 3590, XP055170896, DOI: 10.1074/jbc.M113.513366
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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