Title:
HETERODIMERIC FUSION PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/078479
Kind Code:
A1
Abstract:
The present invention relates to a heterodimeric fusion protein and the use thereof. The heterodimeric fusion protein of the present invention comprises: a first heavy chain, wherein the first heavy chain comprises a first Fc region and an immunomodulator fused with the first Fc region; and a light chain and a second heavy chain, wherein the second heavy chain comprises a second Fc region, and the light chain complexes with the second heavy chain to form a targeting moiety exhibiting the binding specificity to a tumor antigen or an immune checkpoint. The light chain complexes with the first heavy chain and the second heavy chain to form the heterodimeric fusion protein. The heterodimeric fusion protein of the present invention can be used for the targeted treatment of digestive tract cancer, especially colon cancer, and has a high targeting property, and has a tumor inhibition effect significantly superior to that of cetuximab, which has the same target as that of the heterodimeric fusion protein.
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Inventors:
WU CHONGBING (CN)
YIN LIUSONG (CN)
JIANG XIAOLING (CN)
YIN LIUSONG (CN)
JIANG XIAOLING (CN)
Application Number:
PCT/CN2023/123701
Publication Date:
April 18, 2024
Filing Date:
October 10, 2023
Export Citation:
Assignee:
SHENGHE CHINA BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K39/395; A61K38/00; A61K38/20; A61K47/50; A61P35/00; C07K14/54; C07K16/28; C07K19/00; C12N5/10; C12N15/62; C12N15/63
Domestic Patent References:
| WO2022140797A1 | 2022-06-30 | |||
| WO2023046047A1 | 2023-03-30 |
Foreign References:
| CN111132998A | 2020-05-08 |
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