Title:
HIGH-AFFINITY TCR FOR NY-ESO
Document Type and Number:
WIPO Patent Application WO/2018/099402
Kind Code:
A1
Abstract:
Provided is a T cell receptor (TCR) having a property of binding to a SLLMWITQC-HLA A2 complex; and the binding affinity of the TCR to the SLLMWITQC-HLA A2 complex is at least twice that of a wild-type TCR to the SLLMWITQC-HLA A2 complex. Also provided is a fusion molecule of such a TCR with a therapeutic agent. Such a TCR can be used alone or in combination with a therapeutic agent so as to target tumour cells presenting the SLLMWITQC-HLA A2 complex.
Inventors:
LI YI (CN)
HUANG JINHUA (CN)
HUANG JINHUA (CN)
Application Number:
PCT/CN2017/113631
Publication Date:
June 07, 2018
Filing Date:
November 29, 2017
Export Citation:
Assignee:
GUANGDONG XIANGXUE LIFE SCIENCES LTD (CN)
International Classes:
C07K14/725; A61K38/17; A61P35/00; C12N5/10; C12N15/12; C12N15/63
Domestic Patent References:
| WO2014206304A1 | 2014-12-31 |
Foreign References:
| CN105985427A | 2016-10-05 | |||
| CN103249430A | 2013-08-14 | |||
| CN2015093806W | 2015-11-04 | |||
| CN2016077680W | 2016-03-29 |
Other References:
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SAMBROOKRUSSELL ET AL.: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PUBLISHING COMPANY
RASHTCHIAN, CURR OPIN BIOTECHNOL, vol. 6, no. 1, 1995, pages 30 - 6
LI ET AL., NATURE BIOTECH, vol. 23, no. 3, 2005, pages 349 - 354
KOPPE ET AL., CANCER METASTASIS REVIEWS, vol. 24, 2005, pages 539
CHAUDHARY ET AL., NATURE, vol. 339, 1989, pages 394
EPEL ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 51, 2002, pages 565
GILLIES ET AL., NATIONAL ACADEMY OF SCIENCES (PNAS, vol. 89, 1992, pages 1428
CARD ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 53, 2004, pages 345
HALIN ET AL., CANCER RESEARCH, vol. 63, 2003, pages 3202
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ZHU ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 62, 1995, pages 319
LAPOTKO ET AL., CANCER LETTERS, vol. 239, 2005, pages 36
HUANG ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 2115
PENG ET AL., GENE THERAPY, vol. 11, 2004, pages 1234
MAMOT ET AL., CANCER RESEARCH, vol. 65, 2005, pages 11631
ROBBINS ET AL., J. IMMUNOL., vol. 180, 2008, pages 6116 - 6131
ROSENBERG ET AL., NAT REV CANCER, vol. 8, no. 4, 2008, pages 299 - 308
"Remington's Pharmaceutical Sciences", 1991, MACK PUB. CO.
SAMBROOKRUSSELL: "Molecular Cloning a Laboratory Manual"
See also references of EP 3549954A4
SAMBROOKRUSSELL ET AL.: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PUBLISHING COMPANY
RASHTCHIAN, CURR OPIN BIOTECHNOL, vol. 6, no. 1, 1995, pages 30 - 6
LI ET AL., NATURE BIOTECH, vol. 23, no. 3, 2005, pages 349 - 354
KOPPE ET AL., CANCER METASTASIS REVIEWS, vol. 24, 2005, pages 539
CHAUDHARY ET AL., NATURE, vol. 339, 1989, pages 394
EPEL ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 51, 2002, pages 565
GILLIES ET AL., NATIONAL ACADEMY OF SCIENCES (PNAS, vol. 89, 1992, pages 1428
CARD ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 53, 2004, pages 345
HALIN ET AL., CANCER RESEARCH, vol. 63, 2003, pages 3202
MOSQUERA ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 174, 2005, pages 4381
ZHU ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 62, 1995, pages 319
LAPOTKO ET AL., CANCER LETTERS, vol. 239, 2005, pages 36
HUANG ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 2115
PENG ET AL., GENE THERAPY, vol. 11, 2004, pages 1234
MAMOT ET AL., CANCER RESEARCH, vol. 65, 2005, pages 11631
ROBBINS ET AL., J. IMMUNOL., vol. 180, 2008, pages 6116 - 6131
ROSENBERG ET AL., NAT REV CANCER, vol. 8, no. 4, 2008, pages 299 - 308
"Remington's Pharmaceutical Sciences", 1991, MACK PUB. CO.
SAMBROOKRUSSELL: "Molecular Cloning a Laboratory Manual"
See also references of EP 3549954A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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