Title:
HIGH-AFFINITY TCR FOR RECOGNIZING AFP ANTIGEN
Document Type and Number:
WIPO Patent Application WO/2021/185368
Kind Code:
A1
Abstract:
Provided is a T-cell receptor (TCR) that can bind to a KWVESIFLIF-HLA A2402 complex, wherein the binding affinity thereof is at least 2 times that of a wild-type TCR. Further provided is a fusion molecule of the TCR with a therapeutic agent, which fusion molecule targets a tumor cell presenting the KWVESIFLIF-HLA A2402 complex.
Inventors:
LI YI (CN)
PENG ZHEN (CN)
ZHENG HONGJUN (CN)
WU WANLI (CN)
PENG ZHEN (CN)
ZHENG HONGJUN (CN)
WU WANLI (CN)
Application Number:
PCT/CN2021/081897
Publication Date:
September 23, 2021
Filing Date:
March 19, 2021
Export Citation:
Assignee:
XLIFESC LTD (CN)
International Classes:
C07K14/725; A61K39/00; A61K48/00; A61P35/00; C12N5/10; C12N15/12; C12N15/867
Domestic Patent References:
| WO2014206304A1 | 2014-12-31 |
Foreign References:
| CN106336457A | 2017-01-18 | |||
| CN106084036A | 2016-11-09 | |||
| CN106478807A | 2017-03-08 | |||
| CN104087592A | 2014-10-08 |
Other References:
OZAWA, T. ET AL.: "Comprehensive Analysis of the Functional TCR Repertoire at the Single-cell Level", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 367, no. 4, 21 March 2008 (2008-03-21), XP022449879, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2008.01.011
DATABASE PROTEIN 22 July 2015 (2015-07-22), ANONYMOUS: "T cell receptor alpha chain V-J-region, partial [Homo sapiens]", XP055851736, retrieved from NCBI Database accession no. BAS02850
DATABASE PROTEIN 22 July 2015 (2015-07-22), ANONYMOUS: "T cell receptor beta chain V-D-J-region, partial [Homo sapiens]", XP055851737, retrieved from NCBI Database accession no. BAS04084
BUTTERFIELD ET AL., J IMMUNOL., vol. 166, no. 8, 15 April 2001 (2001-04-15)
LI ET AL., NATURE BIOTECH, vol. 23, no. 3, 2005, pages 349 - 354
KOPPE ET AL., CANCER METASTASIS REVIEWS, vol. 24, 2005, pages 539
CHAUDHARY ET AL., NATURE, vol. 339, 1989, pages 394
EPEL ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 51, 2002, pages 565
GILLIES ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (PNAS, vol. 89, 1992, pages 1428
CARD ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 53, 2004, pages 345
HALIN ET AL., CANCER RESEARCH, vol. 63, 2003, pages 3202
MOSQUERA ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 174, 2005, pages 4381
ZHU ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 62, 1995, pages 319
LAPOTKO ET AL., CANCER LETTERS, vol. 239, 2005, pages 36
HUANG ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 2115
PENG ET AL., GENE THERAPY, vol. 11, 2004, pages 1234
MAMOT ET AL., CANCER RESEARCH, vol. 65, 2005, pages 11631
ROBBINS ET AL., J. IMMUNOL., vol. 180, 2008, pages 6116 - 6131
ROSENBERG ET AL., NAT REV CANCER, vol. 8, no. 4, 2008, pages 299 - 308
SAMBROOKRUSSELL ET AL.: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PUBLISHING
See also references of EP 4122956A4
DATABASE PROTEIN 22 July 2015 (2015-07-22), ANONYMOUS: "T cell receptor alpha chain V-J-region, partial [Homo sapiens]", XP055851736, retrieved from NCBI Database accession no. BAS02850
DATABASE PROTEIN 22 July 2015 (2015-07-22), ANONYMOUS: "T cell receptor beta chain V-D-J-region, partial [Homo sapiens]", XP055851737, retrieved from NCBI Database accession no. BAS04084
BUTTERFIELD ET AL., J IMMUNOL., vol. 166, no. 8, 15 April 2001 (2001-04-15)
LI ET AL., NATURE BIOTECH, vol. 23, no. 3, 2005, pages 349 - 354
KOPPE ET AL., CANCER METASTASIS REVIEWS, vol. 24, 2005, pages 539
CHAUDHARY ET AL., NATURE, vol. 339, 1989, pages 394
EPEL ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 51, 2002, pages 565
GILLIES ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (PNAS, vol. 89, 1992, pages 1428
CARD ET AL., CANCER IMMUNOLOGY AND IMMUNOTHERAPY, vol. 53, 2004, pages 345
HALIN ET AL., CANCER RESEARCH, vol. 63, 2003, pages 3202
MOSQUERA ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 174, 2005, pages 4381
ZHU ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 62, 1995, pages 319
LAPOTKO ET AL., CANCER LETTERS, vol. 239, 2005, pages 36
HUANG ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 2115
PENG ET AL., GENE THERAPY, vol. 11, 2004, pages 1234
MAMOT ET AL., CANCER RESEARCH, vol. 65, 2005, pages 11631
ROBBINS ET AL., J. IMMUNOL., vol. 180, 2008, pages 6116 - 6131
ROSENBERG ET AL., NAT REV CANCER, vol. 8, no. 4, 2008, pages 299 - 308
SAMBROOKRUSSELL ET AL.: "Molecular Cloning-A Laboratory Manual", 2001, CSHL PUBLISHING
See also references of EP 4122956A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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