Title:
HIGH-CONCENTRATION PROTEIN FORMULATIONS AND METHOD OF MANUFACTURE
Document Type and Number:
WIPO Patent Application WO2003032907
Kind Code:
A9
Abstract:
Provided is a pharmaceutical composition involving a concentrated mixture of a precipitated protein and a liquid medium and a method for manufacturing the concentrated mixture. The concentrated mixture is manufacturable by precipitation of a protein with a biocompatible polymer precipitating agent, followed by removal of sufficient liquid to concentrate the resulting mixture to the desired degree. The precipitated protein can be stored for a significant time in the concentrated mixture, such as intermediate between processing stages during manufacture operations.
Inventors:
ETTER JEFFREY B
SAMANIEGO ADRIAN C
CARPENTER JOHN F
SAMANIEGO ADRIAN C
CARPENTER JOHN F
Application Number:
PCT/US2002/032872
Publication Date:
January 06, 2005
Filing Date:
October 16, 2002
Export Citation:
Assignee:
RXKINETIX INC (US)
UNIV COLORADO (US)
UNIV COLORADO (US)
International Classes:
A61K9/00; A61K9/10; A61K9/14; A61K38/00; A61K39/395; A61K47/10; A61K47/22; A61K47/26; A61K47/34; A61P19/02; A61P29/00; A61P35/00; C07K1/02; (IPC1-7): A61K38/00
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