Title:
HIGH-EFFICIENCY AND LOW-TOXICITY DNA AND RNA LIPID DELIVERY CARRIER
Document Type and Number:
WIPO Patent Application WO/2023/109881
Kind Code:
A1
Abstract:
Provided in the present invention is a high-efficiency and low-toxicity DNA and RNA lipid delivery carrier. In order to enrich the types of nucleic acid drug delivery carriers, improve the in-vivo delivery and expression effects of the nucleic acid drug and reduce the toxicity and side effects, a new ionizable lipid compound having a special structure is provided in the present invention. The compound has a good binding effect with a negatively-charged nucleic acid, which effectively prevents the premature degradation of the nucleic acid by a nuclease in a cell and facilitates the passage of a liposome loaded with the nucleic acid through a cell membrane. Effective degradation and rapid removal can be achieved, the toxicity and side effects of the nucleic acid drug are reduced, and a nucleic acid drug delivery carrier truly having a high transfection efficiency, a high expression level and a low toxicity can be formed.
Inventors:
CUI YANFANG (CN)
JI SHUAIJIE (CN)
ZHANG BAOQIAN (CN)
JI SHUAIJIE (CN)
ZHANG BAOQIAN (CN)
Application Number:
PCT/CN2022/139186
Publication Date:
June 22, 2023
Filing Date:
December 15, 2022
Export Citation:
Assignee:
UNIV CENTRAL CHINA NORMAL (CN)
International Classes:
C07C229/16; A61K9/19; A61K31/7105; A61K31/713; A61K47/18
Domestic Patent References:
| WO2006006196A2 | 2006-01-19 | |||
| WO2017118842A1 | 2017-07-13 | |||
| WO2021156469A1 | 2021-08-12 |
Foreign References:
| CN114262275A | 2022-04-01 | |||
| CN114163345A | 2022-03-11 | |||
| CN114191561A | 2022-03-18 | |||
| CN103380113A | 2013-10-30 | |||
| CN106661138A | 2017-05-10 |
Other References:
TWYMAN LANCE J., ANTHONY E. BEEZER AND JOHN C. MITCHEL: "An Approach for the Rapid Synthesis of Moderately Sized Dendritic MacromoIecules", J. CHEM. SOC. PERKIN TRANS. 1, vol. 1994, no. 4, 1 January 1994 (1994-01-01), pages 407 - 411, XP093070972
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TRADEMARK AGENCY, LTD. (CN)
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