A HIGH-INTENSITY FOCUSED ULTRASOUND PLASMID ADJUVANT AND ITS USE

Title:

A HIGH-INTENSITY FOCUSED ULTRASOUND PLASMID ADJUVANT AND ITS USE

Document Type and Number:

WIPO Patent Application WO/2006/072197

Kind Code:

A1

Abstract:

A plasmid adjuvant that can increase the energy deposition of the target region when conducting HIFU therapy and si in the form of a biocompatible nanometer solid. Another adjuvant for HIFU therapyof the invention includes a discontinuous phase consisting of film-forming materials and a continuous phase consisting of aqueous medium, wherein the discontinuous phase is evenly dispersed in the continuous phase, the particle size of the discontinuous phase is 10-1000 nm, the amount of the film-forming materials in the adjuvant is 0.1-100 g/L, and the core materials is a biocompatible nanometer solid chosen from magnetic materials, hydroxyapatite and calcium carbonate and its amount in the adjuvant is 0.1150 g/L. The plasmid adjuvant fot HIFU therapy improves significantly the sound environment of target regions, increases the energy deposition of the target regions when conducting HIFU therapy, and consequently, enhances evidently the clinical effects of HIFU against tumor cells. It also provides the use of plasmid adjuvant fot HIFU during the process of the HIFU therapy.

Inventors:

WANG ZHIBIAO (CN)
LI FAQI (CN)
LIU LIPING (CN)
XIAO YANBING (CN)
XIAO ZIWEN (CN)
WANG ZHILONG (CN)

Application Number:

PCT/CN2005/001361

Publication Date:

July 13, 2006

Filing Date:

August 30, 2005

Export Citation:

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Assignee:

CHONGQING HAIFU HIFU TECH CO (CN)
WANG ZHIBIAO (CN)
LI FAQI (CN)
LIU LIPING (CN)
XIAO YANBING (CN)
XIAO ZIWEN (CN)
WANG ZHILONG (CN)

International Classes:

A61K49/00; A61K33/00; A61K49/22

Foreign References:

US4767610A	1988-08-30
US5344640A	1994-09-06

Other References: