Title:
HIGH-PERFORMANCE MATURE INTESTINAL ORGANOID REGENERATIVE THERAPEUTIC AGENT DERIVED FROM PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2024/063533
Kind Code:
A1
Abstract:
The present invention relates to a high-performance mature human intestinal organoid regenerative therapeutic agent derived from pluripotent stem cells. The high-performance mature human intestinal organoid regenerative therapeutic agent derived from pluripotent stem cells according to the present invention includes peristromal cell layers containing mesenchymal stromal cells, derived from the intestine, as the microenvironment around the intestine. That is, the high-performance mature human intestinal organoid regenerative therapeutic agent derived from pluripotent stem cells according to the present invention can exhibit high engraftment ability when transplanted together with peripheral cell layers around intestinal organoids and can exhibit superior regenerative ability through intestinal stem cells present in mature intestinal organoids, and therefore is likely to be useful as a regenerative therapeutic agent.
Inventors:
SON MI-YOUNG (KR)
LEE HANA (KR)
CHOI EUNHO (KR)
LEE HANA (KR)
CHOI EUNHO (KR)
Application Number:
PCT/KR2023/014267
Publication Date:
March 28, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C12N5/071; A61K35/28; A61K35/38; A61K47/34; A61K47/42; A61P1/04; C12N5/077
Domestic Patent References:
| WO2022168908A1 | 2022-08-11 |
Foreign References:
| KR102146274B1 | 2020-08-24 |
Other References:
JUNG KWANG BO, LEE HANA, SON YE SEUL, LEE MI-OK, KIM YOUNG-DAE, OH SOO JIN, KWON OHMAN, CHO SUNWHA, CHO HYUN-SOO, KIM DAE-SOO, OH : "Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 9, no. 1, 2 August 2018 (2018-08-02), UK, pages 3039, XP093150095, ISSN: 2041-1723, DOI: 10.1038/s41467-018-05450-8
JASON R. SPENCE, CHRISTOPHER N. MAYHEW, SCOTT A. RANKIN, MATTHEW F. KUHAR, JEFFERSON E. VALLANCE, KATHRYN TOLLE, ELIZABETH E. HOS: "Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro", NATURE, vol. 470, no. 7332, 3 February 2011 (2011-02-03), pages 105 - 109 + 1, XP002743856, DOI: 10.1038/nature09691
WATSON CAREY L; MAHE MAXIME M; MúNERA JORGE; HOWELL JONATHAN C; SUNDARAM NAMBIRAJAN; POLING HOLLY M; SCHWEITZER JAMIE I; VALL: "Anmodel of human small intestine using pluripotent stem cells", NATURE MEDICINE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 20, no. 11, 19 October 2014 (2014-10-19), New York, pages 1310 - 1314, XP037104196, ISSN: 1078-8956, DOI: 10.1038/nm.3737
JASON R. SPENCE, CHRISTOPHER N. MAYHEW, SCOTT A. RANKIN, MATTHEW F. KUHAR, JEFFERSON E. VALLANCE, KATHRYN TOLLE, ELIZABETH E. HOS: "Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro", NATURE, vol. 470, no. 7332, 3 February 2011 (2011-02-03), pages 105 - 109 + 1, XP002743856, DOI: 10.1038/nature09691
WATSON CAREY L; MAHE MAXIME M; MúNERA JORGE; HOWELL JONATHAN C; SUNDARAM NAMBIRAJAN; POLING HOLLY M; SCHWEITZER JAMIE I; VALL: "Anmodel of human small intestine using pluripotent stem cells", NATURE MEDICINE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 20, no. 11, 19 October 2014 (2014-10-19), New York, pages 1310 - 1314, XP037104196, ISSN: 1078-8956, DOI: 10.1038/nm.3737
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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