Title:
HIGH-POTENTIAL HYDROPHOBIC POLYPEPTIDE MONOLAYER MEMBRANE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/021704
Kind Code:
A1
Abstract:
A polypeptide monolayer membrane having a high surface potential and hydrophobicity, preparation therefor, and application thereof. The polypeptide is composed of a polypeptide molecule having a molecular weight of (1.48 ± 0.2) × 105 g/mol. The thickness of the monolayer membrane is 17.3 to 18.5 nm. The exposure of primary amino groups on the membrane surface is 11 to 11.8%, and the Zeta potential of the polypeptide monolayer membrane is −3 to −2 mV. The contact angle of the membrane is 84 ± 1°. The surface of the polypeptide monolayer membrane has a micro-nano structure, enabling the polypeptide monolayer membrane to have a certain hydrophobic property beneficial to the waterproofing of a biomimetic skin surface. Additionally, the surface of the polypeptide monolayer membrane has a higher potential, which can improve biocompatibility, blood compatibility, and cell adhesion, proliferation, and differentiation capabilities.
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Inventors:
XU JING (CN)
BAN QING (CN)
LI TIANDUO (CN)
ZHANG ZHEN (CN)
MA HUIJUN (CN)
BAN QING (CN)
LI TIANDUO (CN)
ZHANG ZHEN (CN)
MA HUIJUN (CN)
Application Number:
PCT/CN2020/131565
Publication Date:
February 03, 2022
Filing Date:
November 25, 2020
Export Citation:
Assignee:
UNIV QILU TECHNOLOGY (CN)
International Classes:
A61L27/22; A61L27/18; A61L27/24; A61L27/60
Domestic Patent References:
| WO2005121171A1 | 2005-12-22 | |||
| WO2003020425A1 | 2003-03-13 |
Foreign References:
| CN101365724A | 2009-02-11 | |||
| CN111888525A | 2020-11-06 | |||
| US20040151766A1 | 2004-08-05 | |||
| JPH02214726A | 1990-08-27 | |||
| CN101411901A | 2009-04-22 | |||
| CN101151148A | 2008-03-26 |
Attorney, Agent or Firm:
ZHUSEN INTELLECTUAL PROPERTY AGENCY OFFICE (CN)
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