Title:
HIGH-POTENTIAL PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2021/201286
Kind Code:
A1
Abstract:
High-potential pluripotent stem cells according to the present invention have: the properties of conventional pluripotent stem cells, that is, the ability to be differentiated into an embryonic tissue which is all cells making up the body; and the ability to be differentiated into a germ line and/or cells of an extraembryonic tissue such as the placenta, that is, a differentiation ability similar to totipotency. Accordingly, since the high-potential pluripotent stem cells have the ability to be differentiated into cells of an embryonic tissue such as the placenta, in addition to conventional regenerative medicine for various diseases with all injuries in the body, a damaged site of the extraembryonic tissue can be reconstituted to improve or recover the functions of the damaged site, and the high-potential pluripotent stem cells can be applied to new fields of regenerative medicine, such as being able to be used for a treatment pertaining to reproduction such as an infertility treatment.
Inventors:
DEZAWA MARI (JP)
KUSHIDA YOSHIHIRO (JP)
KUSHIDA YOSHIHIRO (JP)
Application Number:
PCT/JP2021/014365
Publication Date:
October 07, 2021
Filing Date:
April 02, 2021
Export Citation:
Assignee:
UNIV TOHOKU (JP)
LIFE SCIENCE INST INC (JP)
LIFE SCIENCE INST INC (JP)
International Classes:
C12N5/0775; A61K35/28; A61K35/50; A61K35/51; A61L27/38; A61P43/00
Domestic Patent References:
| WO2012133942A1 | 2012-10-04 | |||
| WO2011007900A1 | 2011-01-20 | |||
| WO2014027684A1 | 2014-02-20 | |||
| WO2018235834A1 | 2018-12-27 | |||
| WO2011007900A1 | 2011-01-20 |
Foreign References:
| JP5185443B2 | 2013-04-17 | |||
| JP2015159895A | 2015-09-07 | |||
| JP2020503375W |
Other References:
LENG ZIKUAN, SUN DONGMING, HUANG ZIHAO, TADMORI IMAN, CHIANG NING, KETHIDI NIKHIT, SABRA AHMED, KUSHIDA YOSHIHIRO, FU YU-SHOW, DEZ: "Quantitative Analysis of SSEA3+ Cells from Human Umbilical Cord after Magnetic Sorting", CELL TRANSPLANTATION, SAGE, US, vol. 28, no. 7, 1 July 2019 (2019-07-01), US , pages 907 - 923, XP055923958, ISSN: 0963-6897, DOI: 10.1177/0963689719844260
PAVON LORENA FAVARO, SIBOV TATIANA TAIS, DE OLIVEIRA DANIELA MARA, MARTI LUCIANA C, CABRAL FRANCISCO ROMERO, DE SOUZA JEAN GABRIEL: "Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells", ONCOTARGET, IMPACT JOURNALS LLC, UNITED STATES, 28 June 2016 (2016-06-28), United States, pages 40546 - 40557, XP055923963, Retrieved from the Internet [retrieved on 20220523], DOI: 10.18632/oncotarget.9658
KURODA Y ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 8639 - 8643
WAKAO S ET AL., PROC NATL ACAD SCI USA, vol. 108, 2011, pages 9875 - 9880
KURODA Y ET AL., NAT PROTC, vol. 8, 2013, pages 1391 - 1415
OGURA F. ET AL., STEM CELLS DEV, vol. 23, 2014, pages 717 - 728
L. WEINBERGERM. AYYASHN. NOVERSHTERNJ. H. HANNA: "Dynamic stem cell states: naive to primed pluripotency in rodents and humans", NAT. REV. MOL. CELL BIOL., vol. 17, 2016, pages 155 - 169
M. UEDAY. TAKASHIMA: "History of Pluripotent Stem Cells and Human Naive Pluripotent Stem Cells", CYTOMETRY RESEARCH, vol. 27, 2017, pages 19 - 24
KIICHIRO TOMODA, BIOCHEMISTRY, vol. 90, no. 2, 2018, pages 187 - 191
YABE, S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 113, 2016, pages E2598 - 2607
SUDHEER, S ET AL., STEM CELLS DEV, vol. 21, 2012, pages 2987 - 3000
JONGJIN PARK ET AL.: "DSG2 Is a Functional Cell Surface Marker for Identification and Isolation of Human Pluripotent Stem Cells", STEM CELL REPORTS, vol. 11, 2018, pages 115 - 127
PAVON LORENA FAVARO, SIBOV TATIANA TAIS, DE OLIVEIRA DANIELA MARA, MARTI LUCIANA C, CABRAL FRANCISCO ROMERO, DE SOUZA JEAN GABRIEL: "Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells", ONCOTARGET, IMPACT JOURNALS LLC, UNITED STATES, 28 June 2016 (2016-06-28), United States, pages 40546 - 40557, XP055923963, Retrieved from the Internet
KURODA Y ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 8639 - 8643
WAKAO S ET AL., PROC NATL ACAD SCI USA, vol. 108, 2011, pages 9875 - 9880
KURODA Y ET AL., NAT PROTC, vol. 8, 2013, pages 1391 - 1415
OGURA F. ET AL., STEM CELLS DEV, vol. 23, 2014, pages 717 - 728
L. WEINBERGERM. AYYASHN. NOVERSHTERNJ. H. HANNA: "Dynamic stem cell states: naive to primed pluripotency in rodents and humans", NAT. REV. MOL. CELL BIOL., vol. 17, 2016, pages 155 - 169
M. UEDAY. TAKASHIMA: "History of Pluripotent Stem Cells and Human Naive Pluripotent Stem Cells", CYTOMETRY RESEARCH, vol. 27, 2017, pages 19 - 24
KIICHIRO TOMODA, BIOCHEMISTRY, vol. 90, no. 2, 2018, pages 187 - 191
YABE, S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 113, 2016, pages E2598 - 2607
SUDHEER, S ET AL., STEM CELLS DEV, vol. 21, 2012, pages 2987 - 3000
JONGJIN PARK ET AL.: "DSG2 Is a Functional Cell Surface Marker for Identification and Isolation of Human Pluripotent Stem Cells", STEM CELL REPORTS, vol. 11, 2018, pages 115 - 127
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
Download PDF: