Title:
HIGH-SWELLING HYALURONIC ACID BEAD GEL
Document Type and Number:
WIPO Patent Application WO/2023/282413
Kind Code:
A1
Abstract:
The present invention relates to a homogeneous spherical hyaluronic acid bead gel having a swelling degree of 4,500%-10,000%, which is prepared through a mixed crosslinking reaction step, a second step of crosslinking reaction of a dispersion crosslinking reaction, and a third step of purification reaction, wherein the ratio of the reaction time in the mixed crosslinking reaction step to the reaction time in the dispersion crosslinking step is 1:24 to 1:72. According to the method for preparing a hyaluronic acid bead gel of the present invention, it is possible to prepare a transparent, homogeneous bead gel with a high swelling degree. The hyaluronic acid spherical bead gel has a transparent spherical shape with a selected size, exhibits a decomposition period, viscoelasticity, and a swelling degree, has excellent biocompatibility, and is very stable against heat and enzymes.
Inventors:
WOO SANG UK (KR)
CHO KWANG YONG (KR)
CHO KWANG YONG (KR)
Application Number:
PCT/KR2021/019626
Publication Date:
January 12, 2023
Filing Date:
December 22, 2021
Export Citation:
Assignee:
YU CO LTD (KR)
International Classes:
C08B37/08; C08B37/00
Foreign References:
| KR20080073419A | 2008-08-11 | |||
| JP2011506719A | 2011-03-03 | |||
| US4582865A | 1986-04-15 | |||
| KR20070004159A | 2007-01-09 | |||
| US6066340A | 2000-05-23 | |||
| US6039970A | 2000-03-21 | |||
| KR100548965B1 | 2006-02-02 | |||
| KR101553233B1 | 2015-09-15 | |||
| KR102108552B1 | 2020-05-08 |
Other References:
SEUNGHUN SHIN: "Studies on the preparation and characteristic of cross-linked hyaluronic acid bead", 1 February 2005 (2005-02-01), Korea, pages 1 - 61, XP009542557
S. T. LIMG. P. MARTIND. J. BERRYM. B. BROWN, JOURNAL OF CONTROLLED RELEASE, vol. 66, 2000, pages 281 - 292
S. T. LIMB. FORBESD. J. BERRYG. P. MARTINM. B. BROWN, INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 1, no. 231, 2002, pages 73 - 82
POLYMER(KOREA, vol. 29, no. 5, 2005, pages 445 - 450
BIOMATERIALS RESEARCH, vol. 13, no. 3, 2009, pages 105 - 108
BIOMATERIALS RESEARCH, vol. 14, no. 4, 2010, pages 157 - 160
CHUN ET AL., BIOMATERIALS RESEARCH, vol. 20, 2016, pages 24
JOURNAL OF KIPS, vol. 11, no. 03, 2009, pages 30
S. T. LIMG. P. MARTIND. J. BERRYM. B. BROWN, JOURNAL OF CONTROLLED RELEASE, vol. 66, 2000, pages 281 - 292
S. T. LIMB. FORBESD. J. BERRYG. P. MARTINM. B. BROWN, INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 1, no. 231, 2002, pages 73 - 82
POLYMER(KOREA, vol. 29, no. 5, 2005, pages 445 - 450
BIOMATERIALS RESEARCH, vol. 13, no. 3, 2009, pages 105 - 108
BIOMATERIALS RESEARCH, vol. 14, no. 4, 2010, pages 157 - 160
CHUN ET AL., BIOMATERIALS RESEARCH, vol. 20, 2016, pages 24
JOURNAL OF KIPS, vol. 11, no. 03, 2009, pages 30
Attorney, Agent or Firm:
SEO, Young Ho (KR)
Download PDF: