Title:
HIGH THROUGHPUT ASSAY SYSTEMS AND METHODS
Document Type and Number:
WIPO Patent Application WO2000070353
Kind Code:
A3
Abstract:
Pre-screened libraries, such as pre-screened chemical composition libraries useful for drug screening, are generated using target independent assays. The methods typically involve screening of master libraries in microfluidic devices for effects that are correlated to one or more target independent parameter. Also included are multi-module workstations, such as microfluidic workstations,and integrated systems, for performing target independent assays.
Inventors:
HODGE C NICHOLAS (US)
KNAPP MICHAEL R (US)
KOPF-SILL ANNE R (US)
NIKIFOROV THEO T (US)
PARCE J WALLACE (US)
CHOW CALVIN Y H (US)
KNAPP MICHAEL R (US)
KOPF-SILL ANNE R (US)
NIKIFOROV THEO T (US)
PARCE J WALLACE (US)
CHOW CALVIN Y H (US)
Application Number:
PCT/US2000/013200
Publication Date:
April 26, 2001
Filing Date:
May 12, 2000
Export Citation:
Assignee:
CALIPER TECHN CORP (US)
HODGE C NICHOLAS (US)
KNAPP MICHAEL R (US)
KOPF SILL ANNE R (US)
NIKIFOROV THEO T (US)
PARCE J WALLACE (US)
CHOW CALVIN Y H (US)
HODGE C NICHOLAS (US)
KNAPP MICHAEL R (US)
KOPF SILL ANNE R (US)
NIKIFOROV THEO T (US)
PARCE J WALLACE (US)
CHOW CALVIN Y H (US)
International Classes:
G01N33/50; C12M1/34; C12Q1/00; C12Q1/02; C12Q1/25; C12Q1/26; C12Q1/34; C12Q1/48; C12Q1/527; G01N33/15; G01N33/53; G01N33/566; G01N37/00; C07B61/00; C40B60/14; (IPC1-7): G01N33/68; G01N1/10
Domestic Patent References:
| WO1998045481A1 | 1998-10-15 | |||
| WO1998038490A1 | 1998-09-03 | |||
| WO1998000231A1 | 1998-01-08 |
Foreign References:
| US5939024A | 1999-08-17 |
Other References:
JULIAN R K ET AL: "METHOD FOR QUANTITATIVELY DIFFERENTIATING CRUDE NATURAL EXTRACTS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ELECTROSPRAY MASS SPECTROMETRY", ANALYTICAL CHEMISTRY,AMERICAN CHEMICAL SOCIETY. COLUMBUS,US, vol. 70, 1998, pages 3249 - 3254, XP000918642, ISSN: 0003-2700
RANDALL OSBORNE: "Caliper, HP Sign $100M deal to develop 'Lab On A Chip'", BIOWORLD TODAY, - 24 July 1997 (1997-07-24), pages 1, XP002152826
MARY WELCH: "Caliper Moving To Genomics, Proteomics With LabChips", BIOWORLD TODAY, - 8 July 1998 (1998-07-08), XP002152827
AGILENT TECHNOLOGIES: "Agilent technologies 2100 Bioanalyzer", PRODUCT INFORMATION, - 1999, pages 1 - 6, XP002152829
CLIFF HENKE, ANNE R. KOPF-SILL: "DNA-chip technologies; Part 2: State-of-the-Art and competing technologies", IVD TECHHNOLOGY MAGAZINE, - 1 November 1998 (1998-11-01), pages 1 - 13, XP002152828
RANDALL OSBORNE: "Caliper, HP Sign $100M deal to develop 'Lab On A Chip'", BIOWORLD TODAY, - 24 July 1997 (1997-07-24), pages 1, XP002152826
MARY WELCH: "Caliper Moving To Genomics, Proteomics With LabChips", BIOWORLD TODAY, - 8 July 1998 (1998-07-08), XP002152827
AGILENT TECHNOLOGIES: "Agilent technologies 2100 Bioanalyzer", PRODUCT INFORMATION, - 1999, pages 1 - 6, XP002152829
CLIFF HENKE, ANNE R. KOPF-SILL: "DNA-chip technologies; Part 2: State-of-the-Art and competing technologies", IVD TECHHNOLOGY MAGAZINE, - 1 November 1998 (1998-11-01), pages 1 - 13, XP002152828
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