Title:
HIGHLY-EFFICIENT MANUFACTURING METHOD OF INDUCED PLURIPOTENT STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS PRODUCED BY THE METHOD
Document Type and Number:
WIPO Patent Application WO/2011/037367
Kind Code:
A2
Abstract:
The present invention relates to a method for manufacturing personalized pluripotent stem cells having the same differentiation potency as embryonic stem cells, which comprises the following steps: preparing protein extracts separated from various types of undifferentiated stem cells induced through a variety of methods (induced Pluripotent Stem cells, iPS); infusing the extracts into adult cells; and deriving pluripotent stem cells having the same differentiation potency as embryonic stem cells by culturing the adult cells infused with the extracts. In addition, the present invention relates to pluripotent stem cells produced by the method and cell therapy products that include pluripotent stem cells. In comparison to conventional manufacturing methods for pluripotent stem cells, the method of the present invention allows pluripotent stem cells to be produced with ease and remarkably high efficiency.
Inventors:
PARK YOUNG-BAE (KR)
KIM HYO-SOO (KR)
KWON YOO-WOOK (KR)
CHO HYUN-JAI (KR)
PAEK JAE-SEUNG (KR)
KIM HYO-SOO (KR)
KWON YOO-WOOK (KR)
CHO HYUN-JAI (KR)
PAEK JAE-SEUNG (KR)
Application Number:
PCT/KR2010/006374
Publication Date:
March 31, 2011
Filing Date:
September 17, 2010
Export Citation:
Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
PARK YOUNG-BAE (KR)
KIM HYO-SOO (KR)
KWON YOO-WOOK (KR)
CHO HYUN-JAI (KR)
PAEK JAE-SEUNG (KR)
PARK YOUNG-BAE (KR)
KIM HYO-SOO (KR)
KWON YOO-WOOK (KR)
CHO HYUN-JAI (KR)
PAEK JAE-SEUNG (KR)
International Classes:
C12N5/074; A61K35/12; C12N5/02
Domestic Patent References:
| WO2011037301A1 | 2011-03-31 |
Foreign References:
| KR20090130582A | 2009-12-24 |
Other References:
RAJASINGH, J. ET AL.: 'Cell-free embryonic stem cell extract mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair' CIRCULATION RESEARCH vol. 102, 15 May 2008, pages E107 - E117
BRU, T. ET AL.: 'Rapid induction of pluripotency genes after exposure human somatic cells to mouse ES cell extracts' EXPERIMENTAL CELL RESEARCH vol. 314, 29 May 2008, pages 2634 - 2642
BRU, T. ET AL.: 'Rapid induction of pluripotency genes after exposure human somatic cells to mouse ES cell extracts' EXPERIMENTAL CELL RESEARCH vol. 314, 29 May 2008, pages 2634 - 2642
Attorney, Agent or Firm:
LEE, MYOUNG-JIN (KR)
이명진 (KR)
이명진 (KR)
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