Title:
HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/031816
Kind Code:
A3
Abstract:
Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.
Inventors:
CHYTIL MILAN (US)
ENGEL SHARON R (US)
FANG QUN KEVIN (US)
ENGEL SHARON R (US)
FANG QUN KEVIN (US)
Application Number:
PCT/US2010/048199
Publication Date:
July 05, 2012
Filing Date:
September 09, 2010
Export Citation:
Assignee:
SUNOVION PHARMACEUTICALS INC (US)
CHYTIL MILAN (US)
ENGEL SHARON R (US)
FANG QUN KEVIN (US)
CHYTIL MILAN (US)
ENGEL SHARON R (US)
FANG QUN KEVIN (US)
International Classes:
C07D471/04; A61K31/551; A61P25/28; C07D471/14; C07D471/18; C07D487/04; C07D487/14; C07D487/18; C07D519/00
Domestic Patent References:
| WO2008116881A1 | 2008-10-02 | |||
| WO2007065820A1 | 2007-06-14 |
Foreign References:
| US4252816A | 1981-02-24 | |||
| US20020002161A1 | 2002-01-03 | |||
| US20020006934A1 | 2002-01-17 | |||
| US6908926B1 | 2005-06-21 |
Other References:
O. CHERKAOUI ET. AL.: "Hétérocyclisation des 2-aminoalkyl (et aryl) benzimidazoles en catalyse par transfert de phase.", BULLETIN DE LA SOCIÉTÉ CHIMIQUE DE FRANCE, vol. 128, 1 February 1991 (1991-02-01), pages 255 - 259, XP009132195
M. B. EL ABBASSI ET. AL.: "Synthèse des pyrazolo[2',3':1,7]diazépino-1,4[4,5-a]benzimidazoles et des 1-alkyl-2-[(5-méthyl-3-pyrazolyl)méthyl]- benzimidazoles.", BULLETIN DE LA SOCIÉTÉ CHIMIQUE DE FRANCE, vol. 127, 1 January 1990 (1990-01-01), pages 117 - 128, XP001094718
J. R. HUFF ET.A L,: "Convenient and Regioselective Synthesis of Substituted 2,3,4,5-Tetrahydro-1H-[1,4]diazepino[1,7-a]benzimidazoles.", JOURNAL OF ORGANIC CHEMISTRY, vol. 47, no. 3, 1 March 1982 (1982-03-01), pages 582 - 585, XP002577911
M. B. EL ABBASSI ET. AL.: "Synthèse des pyrazolo[2',3':1,7]diazépino-1,4[4,5-a]benzimidazoles et des 1-alkyl-2-[(5-méthyl-3-pyrazolyl)méthyl]- benzimidazoles.", BULLETIN DE LA SOCIÉTÉ CHIMIQUE DE FRANCE, vol. 127, 1 January 1990 (1990-01-01), pages 117 - 128, XP001094718
J. R. HUFF ET.A L,: "Convenient and Regioselective Synthesis of Substituted 2,3,4,5-Tetrahydro-1H-[1,4]diazepino[1,7-a]benzimidazoles.", JOURNAL OF ORGANIC CHEMISTRY, vol. 47, no. 3, 1 March 1982 (1982-03-01), pages 582 - 585, XP002577911
Attorney, Agent or Firm:
INSOGNA, Anthony, M. et al. (222 East 41st StreetNew York, NY, US)
Download PDF:
Previous Patent: OCEANIC COMMUNICATIONS SYSTEM
Next Patent: ENERGETIC MATERIAL APPLICATIONS IN SHAPED CHARGES FOR PERFORATION OPERATIONS
Next Patent: ENERGETIC MATERIAL APPLICATIONS IN SHAPED CHARGES FOR PERFORATION OPERATIONS