HISTOLOGICAL ASSESSMENT

WIPO Patent Application WO2004017052

A3

A method of measuring oestrogen or progesterone receptor (ER or PR) comprises identifying in histopathological specimen image data pixel groups indicating cell nuclei, and deriving image hue and saturation. The image is thresholded using hue and saturation and preferentially stained cells identified. ER or PR status is determined from normalised average saturation and proportion of preferentially stained cells. A method of measuring C-erb-2 comprises correlating window functions with pixel sub-groups to identify cell boundaries, computing measures of cell boundary brightness and sharpness and brightness extent around cell boundaries, and comparing the measures with comparison images associated with different values of C-erb-2. A C-erb-2 value associated with a comparison image having similar brightness-related measures is assigned. A method of measuring vascularity comprises deriving image hue and saturation, producing a segmented image by hue and saturation thresholding and identifying contiguous pixels. Vascularity is determined from contiguous pixel area corresponding to vascularity expressed as a proportion of total image area.

HAMER MICHAEL JOHN (GB)
PETROU MARIA (GB)
KESIDIS ANASTASIOS (GR)
VARGA MARGARET JAI (GB)

PCT/GB2003/003465

June 03, 2004

August 08, 2003

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QINETIQ LTD (GB)
HAMER MICHAEL JOHN (GB)
PETROU MARIA (GB)
KESIDIS ANASTASIOS (GR)
VARGA MARGARET JAI (GB)

G01N15/00; G01N21/27; G01J3/46; G01N33/48; G01N33/483; G06K9/00; G06T1/00; G06T7/00; (IPC1-7): G01N15/10; G06F19/00

WO2001004828A1

2001-01-18

US6404916B1	2002-06-11
US20020039434A1	2002-04-04

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