Title:
HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/112447
Kind Code:
A3
Abstract:
The present invention provides novel compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of a compound of the invention to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
Inventors:
MAZITSCHEK RALPH (US)
BRADNER JAMES ELLIOTT (US)
GRACHAN MELISSA (US)
BRADNER JAMES ELLIOTT (US)
GRACHAN MELISSA (US)
Application Number:
PCT/US2012/024868
Publication Date:
December 27, 2012
Filing Date:
February 13, 2012
Export Citation:
Assignee:
DANA FARBER CANCER INST INC (US)
MAZITSCHEK RALPH (US)
BRADNER JAMES ELLIOTT (US)
GRACHAN MELISSA (US)
MAZITSCHEK RALPH (US)
BRADNER JAMES ELLIOTT (US)
GRACHAN MELISSA (US)
International Classes:
C07C69/76; A61K31/165; A61P29/00; C07C215/28
Domestic Patent References:
| WO2002100341A2 | 2002-12-19 | |||
| WO2009055917A1 | 2009-05-07 | |||
| WO2001038322A1 | 2001-05-31 | |||
| WO2005034880A2 | 2005-04-21 |
Foreign References:
| US20070225373A1 | 2007-09-27 | |||
| US20080234297A1 | 2008-09-25 | |||
| US20040267015A1 | 2004-12-30 | |||
| US20040122079A1 | 2004-06-24 | |||
| US7420089B2 | 2008-09-02 | |||
| US20060122234A1 | 2006-06-08 |
Other References:
DUBE, PASCAL ET AL.: "Carbonyldiimidazole-Mediated Lossen Rearrangement", ORGANIC LETTERS, vol. 11, 2009, pages 5622 - 5625
GRIFFITH, DARREN ET AL.: "Ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis, characterisation and in vitro pharmacological evaluation", J. BIOL. INORG. CHEM., vol. 13, 2008, pages 511 - 520
LOUISE-LERICHE, LUDIVINE ET AL.: "A HTS Assay for the Detection of Organophosphorus Nerve Agent Scavengers", CHEM. EUR. J., vol. 16, 2010, pages 3510 - 3523
GRIFFITH, DARREN ET AL.: "Ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis, characterisation and in vitro pharmacological evaluation", J. BIOL. INORG. CHEM., vol. 13, 2008, pages 511 - 520
LOUISE-LERICHE, LUDIVINE ET AL.: "A HTS Assay for the Detection of Organophosphorus Nerve Agent Scavengers", CHEM. EUR. J., vol. 16, 2010, pages 3510 - 3523
Attorney, Agent or Firm:
CORLESS, Peter, F. et al. (P.O. Box 55874Boston, MA, US)
Download PDF: