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Title:
HISTONE METHYLTRANSFERASE EZH2 INHIBITOR, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/137639
Kind Code:
A1
Abstract:
The invention relates to a histone methyltransferase EZH2 inhibitor, a preparation method and pharmaceutical use thereof. In particular, the invention relates to a compound represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing the same, and a use thereof as a histone methyltransferase EZH2 inhibitor for treating diseases associated with the histone methyltransferase EZH2, especially cancer. The definition of each substituents in the general formula (I) is same as the definition in the specification.

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Inventors:
SI JUTONG (CN)
WANG GUAN (CN)
JIANG MEIFENG (CN)
YANG ZHIHE (CN)
ZHOU CHENTAO (CN)
Application Number:
PCT/CN2018/073946
Publication Date:
August 02, 2018
Filing Date:
January 24, 2018
Export Citation:
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Assignee:
ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN)
International Classes:
C07D213/64; A61K31/4412; A61P35/00; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D491/10
Domestic Patent References:
WO2013155464A12013-10-17
WO2016172199A12016-10-27
WO2012149504A12012-11-01
Foreign References:
US20160332969A12016-11-17
CN104039956A2014-09-10
CN104768555A2015-07-08
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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