Title:
HIV REPLICATION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2013/062028
Kind Code:
A1
Abstract:
Provided are a novel compound having an antiviral effect, particularly HIV replication-inhibiting activity, and a medical drug, particularly an anti-HIV drug, containing the same. The compound is represented by
Formula (I)
(where the broken line shows whether or not a bond is present; R1 is an optionally substituted alkyl, and the like; R2 is an optionally substituted alkyloxy, and the like; n is 1 or 2; R3 is an optionally substituted aromatic carbocyclic group, and the like; R4 is a hydrogen atom, and the like; R5 is an optionally aromatic carbocyclic group, and the like; Y is a single bond, and the like; R6 is an optionally substituted alkyl, and the like; R7 is -Z-R71, and the like; Z is -NR72-CO, and the like; R71 is an optionally substituted alkyl, and the like; and R72 is a hydrogen atom and the like).
Inventors:
IWAKI TSUTOMU (JP)
TOMITA KENJI (JP)
TOMITA KENJI (JP)
Application Number:
PCT/JP2012/077544
Publication Date:
May 02, 2013
Filing Date:
October 25, 2012
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07C205/56; A61K31/192; A61K31/27; A61P31/18; C07C229/40; C07C233/33; C07C233/63; C07C233/81; C07C255/57; C07C271/22; C07C275/42; C07C311/14; C07C311/19
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Other References:
GIT FACHZEITSCHRIFT FUER DAS LABORATORIUM, vol. 27, no. 12, 1983, pages 1078 - 1080
AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 64, no. 6, 2011, pages 757 - 765
ACTA CRYSTALLOGRAPHICA, SECTION C, vol. C46, no. 12, 1990, pages 2486 - 2487
SYNLETT, 1990, pages 697 - 699
JOURNAL OF ORGANIC CHEMISTRY, vol. 52, no. 2, 1987, pages 296 - 298
JOURNAL OF NATURAL PRODUCTS, vol. 67, no. 7, 2004, pages 1172 - 1174
"Isotopes in the Physical and Biomedical Sciences", vol. 1, 1987
"Design of Prodrugs", 1985, ELSEVIER
See also references of EP 2772480A4
AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 64, no. 6, 2011, pages 757 - 765
ACTA CRYSTALLOGRAPHICA, SECTION C, vol. C46, no. 12, 1990, pages 2486 - 2487
SYNLETT, 1990, pages 697 - 699
JOURNAL OF ORGANIC CHEMISTRY, vol. 52, no. 2, 1987, pages 296 - 298
JOURNAL OF NATURAL PRODUCTS, vol. 67, no. 7, 2004, pages 1172 - 1174
"Isotopes in the Physical and Biomedical Sciences", vol. 1, 1987
"Design of Prodrugs", 1985, ELSEVIER
See also references of EP 2772480A4
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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Claims: