Title:
HLA-A24- OR HLA-A2-BINDING PEPTIDE OF PARATHYROID HORMONE-RELATED PROTEIN
Document Type and Number:
WIPO Patent Application WO/2005/116056
Kind Code:
A1
Abstract:
A cancer antigen peptide which is a peptide fragment originating in a parathyroid hormone-related protein, can bind to HLA-A24 or HLA-A2 antigen and can be recognized by cytotoxic T lymphocytes or its derivative being equivalent thereto in functional properties is useful in treating and preventing prostatic cancer.
Inventors:
ITOH KYOGO (JP)
HARADA MAMORU (JP)
HARADA MAMORU (JP)
Application Number:
PCT/JP2005/009542
Publication Date:
December 08, 2005
Filing Date:
May 25, 2005
Export Citation:
Assignee:
GREENPEPTIDE CO LTD (JP)
ITOH KYOGO (JP)
HARADA MAMORU (JP)
ITOH KYOGO (JP)
HARADA MAMORU (JP)
International Classes:
A61P19/00; A61P35/00; A61P35/04; C07K7/06; C07K14/47; C07K14/635; C12N5/06; A61K39/00; (IPC1-7): C07K7/06; A61K39/00; A61P19/00; A61P35/00; A61P35/04; C07K14/47; C12N5/06
Foreign References:
| US20050033023A1 | 2005-02-10 |
Other References:
FRANCINI G. ET AL: "High-affinity HLA-A(*)02.01 peptides from parathyroid hormone-related protein generate in vitro and in vivo antitumor CTL response without autoimmune side effects.", J.IMMUNOL., vol. 169, no. 9, 2002, pages 4840 - 4849, XP002990846
CORREALE P. ET AL: "A parathyroid-hormone-related-protein(PHT-rP)-specific cytotoxic T cell response induced by in vitro stimulation of tumor-infiltrating lymphocytes derived from prostate cancer metastases, with epitope peptide-loaded autologous dendritic cells and low-dose IL-2.", J.CANCER., vol. 85, no. 11, 2001, pages 1722 - 1730, XP009006173
YAO A. ET AL: "Identification of parathyroid hormone-related protein-derived peptides immunogenic in human histocompatibility leukocyte antigen-A24+prostate cancer patients.", J.CANCER., vol. 91, no. 2, 2004, pages 287 - 296, XP002990847
See also references of EP 1767541A4
CORREALE P. ET AL: "A parathyroid-hormone-related-protein(PHT-rP)-specific cytotoxic T cell response induced by in vitro stimulation of tumor-infiltrating lymphocytes derived from prostate cancer metastases, with epitope peptide-loaded autologous dendritic cells and low-dose IL-2.", J.CANCER., vol. 85, no. 11, 2001, pages 1722 - 1730, XP009006173
YAO A. ET AL: "Identification of parathyroid hormone-related protein-derived peptides immunogenic in human histocompatibility leukocyte antigen-A24+prostate cancer patients.", J.CANCER., vol. 91, no. 2, 2004, pages 287 - 296, XP002990847
See also references of EP 1767541A4
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7 Shiromi, 1-chome, Chuo-k, Osaka-shi Osaka 01, JP)
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