HLA CLASS II–RESTRICTED DRB T CELL RECEPTORS AGAINST RAS WITH G12D MUTATION

Title:

HLA CLASS II–RESTRICTED DRB T CELL RECEPTORS AGAINST RAS WITH G12D MUTATION

Document Type and Number:

WIPO Patent Application WO/2022/015694

Kind Code:

A8

Abstract:

Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glycine at position 12 with aspartic acid. The TCRs may recognize G12D RAS presented by an HLA-DR heterodimer. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

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Inventors:

LEVIN NOAM (US)
YOSEPH RAMI (US)
CAFRI GAL (IL)
ROSENBERG STEVEN A (US)

Application Number:

PCT/US2021/041375

Publication Date:

January 12, 2023

Filing Date:

July 13, 2021

Export Citation:

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Assignee:

US HEALTH (US)

International Classes:

C07K14/725; A61K38/00

Attorney, Agent or Firm:

LAWLEY, Stephanie M. et al. (US)

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