Title:
HLA-E CHIMERIC MOLECULE
Document Type and Number:
WIPO Patent Application WO2005042693
Kind Code:
A3
Abstract:
It is intended to provide an HLA-E chimeric molecule which inhibits the cytotoxic activity of human NK cells in non-human mammalian cells; a base sequence encoding this chimeric molecule; a non-human mammalian cell transformed by this base sequence; and the corresponding mammal. The above-described HLA-E chimeric molecule is a peptide in which the signal peptide domain, the alpha1 domain and/or the alpha2 domain of HLA-E have been entirely or partly modified. The above-described base sequence is a base sequence encoding this chimeric molecule. A transformant having the above-described base sequence transferred thereinto has an effect of effectively expressing HLA-E.
Inventors:
MIYAGAWA SHUJI (JP)
MATSUNAMI KATSUYOSHI (JP)
MATSUNAMI KATSUYOSHI (JP)
Application Number:
PCT/JP2004/016776
Publication Date:
July 07, 2005
Filing Date:
November 04, 2004
Export Citation:
Assignee:
ANIMAL ENGINEERING RES INST (JP)
MIYAGAWA SHUJI (JP)
MATSUNAMI KATSUYOSHI (JP)
MIYAGAWA SHUJI (JP)
MATSUNAMI KATSUYOSHI (JP)
International Classes:
A01K67/027; C07K14/705; C07K14/74; C12N5/10; C12N15/12; C12N; (IPC1-7): C07K14/705; A01K67/027; C12N5/10; C12N15/12
Other References:
MATSUNAMI, K. ET AL.: "Protection against natural killer-mediated swine endothelial cell lysis by HLA-G and HLA-E.", TRANSPLANT. PROC., vol. 32, no. 5, 2000, pages 939 - 940, XP002988643
BRAUD, V.M. ET AL.: "HLA-E binds to natural killer cell receptors CD94/NKG2A, B an C.", NATURE., vol. 391, no. 6669, 19 February 1998 (1998-02-19), pages 795 - 799, XP002109020
MATSUNAMI, K. ET AL.: "Modulation of the leader peptide sequence of the HLA-E gene up-regulates it's expression and down-regulates natural killer cell-mediate swine endothelial cell lysis.", TRANSPLANTATION., vol. 73, no. 10, 2002, pages 1582 - 1609, XP008049979
ROUAS-FREISS, N. ET AL.: "The alphal domain of HLA-G1 and HLA-G2 inhibits cytotoxocity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?.", PROC.NATL.ACAD.SCI.USA, vol. 94, no. 10, May 1997 (1997-05-01), pages 5249 - 5254, XP002086260
BRAUD, V.M. ET AL.: "HLA-E binds to natural killer cell receptors CD94/NKG2A, B an C.", NATURE., vol. 391, no. 6669, 19 February 1998 (1998-02-19), pages 795 - 799, XP002109020
MATSUNAMI, K. ET AL.: "Modulation of the leader peptide sequence of the HLA-E gene up-regulates it's expression and down-regulates natural killer cell-mediate swine endothelial cell lysis.", TRANSPLANTATION., vol. 73, no. 10, 2002, pages 1582 - 1609, XP008049979
ROUAS-FREISS, N. ET AL.: "The alphal domain of HLA-G1 and HLA-G2 inhibits cytotoxocity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?.", PROC.NATL.ACAD.SCI.USA, vol. 94, no. 10, May 1997 (1997-05-01), pages 5249 - 5254, XP002086260
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