Title:
HNF1 ALPHA AS A TUMOR SUPPRESSOR GENE, AND DIAGNOSTIC AND THERAPEUTIC APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO2004016813
Kind Code:
A3
Abstract:
The present invention relates to diagnostic methods and therapeutics in the field of tumors involving Hepatocyte Nuclear Factor 1a (HNF1a). The invention provides an in vitro method for the diagnosis of a tumor in a patient, which method comprises determining the expression or activity of HNF1a. The invention also provides a HNF1a gene therapy and protein therapy method.
Inventors:
ZUCMAN-ROSSI JESSICA (FR)
LAURENT-PUIG PIERRE (FR)
BLUTEAU OLIVIER (FR)
BIOULAC-SAGE PAULETTE (FR)
JEANNOT EMMANUELLE (FR)
MARQUES JUAN MARTIN (UY)
BALABAUD CHARLES (FR)
LAURENT-PUIG PIERRE (FR)
BLUTEAU OLIVIER (FR)
BIOULAC-SAGE PAULETTE (FR)
JEANNOT EMMANUELLE (FR)
MARQUES JUAN MARTIN (UY)
BALABAUD CHARLES (FR)
Application Number:
PCT/IB2003/003516
Publication Date:
July 22, 2004
Filing Date:
August 14, 2003
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
ZUCMAN-ROSSI JESSICA (FR)
LAURENT-PUIG PIERRE (FR)
BLUTEAU OLIVIER (FR)
BIOULAC-SAGE PAULETTE (FR)
JEANNOT EMMANUELLE (FR)
MARQUES JUAN MARTIN (UY)
BALABAUD CHARLES (FR)
ZUCMAN-ROSSI JESSICA (FR)
LAURENT-PUIG PIERRE (FR)
BLUTEAU OLIVIER (FR)
BIOULAC-SAGE PAULETTE (FR)
JEANNOT EMMANUELLE (FR)
MARQUES JUAN MARTIN (UY)
BALABAUD CHARLES (FR)
International Classes:
C12Q1/68; (IPC1-7): C12Q1/68
Other References:
KALKUHL A ET AL: "Expression of hepatocyte-enriched nuclear transcription factors in mouse liver tumours.", CARCINOGENESIS. ENGLAND MAR 1996, vol. 17, no. 3, March 1996 (1996-03-01), pages 609 - 612, XP008016972, ISSN: 0143-3334
XU L ET AL: "Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma.", CANCER RESEARCH. UNITED STATES 1 APR 2001, vol. 61, no. 7, 1 April 2001 (2001-04-01), pages 3176 - 3181, XP002243262, ISSN: 0008-5472
ANASTASIADIS A G ET AL: "Loss of function of the tissue specific transcription factor HNF1 alpha in renal cell carcinoma and clinical prognosis.", ANTICANCER RESEARCH. GREECE 1999 MAY-JUN, vol. 19, no. 3A, May 1999 (1999-05-01), pages 2105 - 2110, XP008016973, ISSN: 0250-7005
SEL S ET AL: "Human renal cell carcinogenesis is accompanied by a coordinate loss of the tissue specific transcription factors HNF4 alpha and HNF1 alpha.", CANCER LETTERS. IRELAND 29 MAR 1996, vol. 101, no. 2, 29 March 1996 (1996-03-29), pages 205 - 210, XP002243263, ISSN: 0304-3835
ELLARD S: "Hepatocyte nuclear factor 1 alpha (HNF-1 alpha) mutations in maturity-onset diabetes of the young.", HUMAN MUTATION. UNITED STATES NOV 2000, vol. 16, no. 5, November 2000 (2000-11-01), pages 377 - 385, XP008016982, ISSN: 1098-1004
VAXILLAIRE M ET AL: "Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).", HUMAN MOLECULAR GENETICS. ENGLAND APR 1997, vol. 6, no. 4, April 1997 (1997-04-01), pages 583 - 586, XP002243264, ISSN: 0964-6906
AIHARA T ET AL: "Clonal analysis of precancerous lesion of hepatocellular carcinoma.", GASTROENTEROLOGY. UNITED STATES AUG 1996, vol. 111, no. 2, August 1996 (1996-08-01), pages 455 - 461, XP008017099, ISSN: 0016-5085
BACH I ET AL: "Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse.", GENOMICS. UNITED STATES SEP 1990, vol. 8, no. 1, September 1990 (1990-09-01), pages 155 - 164, XP008017098, ISSN: 0888-7543
BOCCACCIO C ET AL: "Chromosomal localization and sequence analysis of a human episomal sequence with in vitro differentiating activity.", SOMATIC CELL AND MOLECULAR GENETICS. UNITED STATES MAY 1994, vol. 20, no. 3, May 1994 (1994-05-01), pages 163 - 170, XP008017100, ISSN: 0740-7750
BLUTEAU OLIVIER ET AL: "Bi-allelic inactivation of TCF1 in hepatic adenomas.", NATURE GENETICS. UNITED STATES OCT 2002, vol. 32, no. 2, October 2002 (2002-10-01), pages 312 - 315, XP002243265, ISSN: 1061-4036
LAURENT-PUIG PIERRE ET AL: "Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability.", GASTROENTEROLOGY. UNITED STATES MAY 2003, vol. 124, no. 5, May 2003 (2003-05-01), pages 1311 - 1314, XP001157544, ISSN: 0016-5085
XU L ET AL: "Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma.", CANCER RESEARCH. UNITED STATES 1 APR 2001, vol. 61, no. 7, 1 April 2001 (2001-04-01), pages 3176 - 3181, XP002243262, ISSN: 0008-5472
ANASTASIADIS A G ET AL: "Loss of function of the tissue specific transcription factor HNF1 alpha in renal cell carcinoma and clinical prognosis.", ANTICANCER RESEARCH. GREECE 1999 MAY-JUN, vol. 19, no. 3A, May 1999 (1999-05-01), pages 2105 - 2110, XP008016973, ISSN: 0250-7005
SEL S ET AL: "Human renal cell carcinogenesis is accompanied by a coordinate loss of the tissue specific transcription factors HNF4 alpha and HNF1 alpha.", CANCER LETTERS. IRELAND 29 MAR 1996, vol. 101, no. 2, 29 March 1996 (1996-03-29), pages 205 - 210, XP002243263, ISSN: 0304-3835
ELLARD S: "Hepatocyte nuclear factor 1 alpha (HNF-1 alpha) mutations in maturity-onset diabetes of the young.", HUMAN MUTATION. UNITED STATES NOV 2000, vol. 16, no. 5, November 2000 (2000-11-01), pages 377 - 385, XP008016982, ISSN: 1098-1004
VAXILLAIRE M ET AL: "Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).", HUMAN MOLECULAR GENETICS. ENGLAND APR 1997, vol. 6, no. 4, April 1997 (1997-04-01), pages 583 - 586, XP002243264, ISSN: 0964-6906
AIHARA T ET AL: "Clonal analysis of precancerous lesion of hepatocellular carcinoma.", GASTROENTEROLOGY. UNITED STATES AUG 1996, vol. 111, no. 2, August 1996 (1996-08-01), pages 455 - 461, XP008017099, ISSN: 0016-5085
BACH I ET AL: "Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse.", GENOMICS. UNITED STATES SEP 1990, vol. 8, no. 1, September 1990 (1990-09-01), pages 155 - 164, XP008017098, ISSN: 0888-7543
BOCCACCIO C ET AL: "Chromosomal localization and sequence analysis of a human episomal sequence with in vitro differentiating activity.", SOMATIC CELL AND MOLECULAR GENETICS. UNITED STATES MAY 1994, vol. 20, no. 3, May 1994 (1994-05-01), pages 163 - 170, XP008017100, ISSN: 0740-7750
BLUTEAU OLIVIER ET AL: "Bi-allelic inactivation of TCF1 in hepatic adenomas.", NATURE GENETICS. UNITED STATES OCT 2002, vol. 32, no. 2, October 2002 (2002-10-01), pages 312 - 315, XP002243265, ISSN: 1061-4036
LAURENT-PUIG PIERRE ET AL: "Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability.", GASTROENTEROLOGY. UNITED STATES MAY 2003, vol. 124, no. 5, May 2003 (2003-05-01), pages 1311 - 1314, XP001157544, ISSN: 0016-5085
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