Title:
HOMOGALACTURONAN, COMPLEX, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/036219
Kind Code:
A1
Abstract:
Provided in the present invention are a homogalacturonan, a complex, and a preparation method therefor and the use thereof. Provided in the present invention is a preparation method for homogalacturonan, comprising the following steps: step 1, pre-treatment to obtain a stable water-soluble pectin gel; step 2, an alkali hydrolysis-microwave method treatment; step 3, a demethoxy treatment; and step 4, ultra-filtration membrane refining. Also provided in the present invention are a complex using the polysaccharide, and a preparation method therefor and the use thereof. The complex of the present invention has a good medical effect, and the preparation method is simple in process, high in yield and low in cost.
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Inventors:
SHEN YANWEI (CN)
YU LU (CN)
YU LU (CN)
Application Number:
PCT/CN2022/117713
Publication Date:
March 16, 2023
Filing Date:
September 08, 2022
Export Citation:
Assignee:
SHANGHAI CATHAYA MEDICAL TECH CO LTD (CN)
International Classes:
C08B37/06; A23L33/105; A23L33/125; A61K31/715; A61K36/752; A61P1/00; A61P29/00; A61P37/04; A61P39/06; C08B37/00
Foreign References:
| CN113480676A | 2021-10-08 | |||
| CN113633689A | 2021-11-12 | |||
| CN112266941A | 2021-01-26 | |||
| CN110652013A | 2020-01-07 | |||
| CN101642275A | 2010-02-10 | |||
| CN110951804A | 2020-04-03 | |||
| CN105647993A | 2016-06-08 | |||
| FR3087440A1 | 2020-04-24 | |||
| CN104593450A | 2015-05-06 |
Other References:
"Master's Thesis", 1 June 2016, JIANGNAN UNIVERSITY, CN, article CHEN, YING: "Preparation of Modified Pectin and the Structure Characteristics of Its Binding to GAL-3", pages: 1 - 65, XP009544387
"Doctoral Dissertation", 15 August 2011, NORTHWEST UNIVERSITY, CN, article LI, JIANJUN: "The Study on the Controlled Degradation of Citrus Pectic Polysaccharide and the Purification and Activity of Oligogalacturonic Acid Fragments", pages: 1 - 106, XP009544388
"Doctoral Dissertation", 1 May 2014, ZHEJIANG UNIVERSITY, CN, article SHEN, YANWEI: "The Synergistic Effect of Low Molecular Weight Citrus Pectin on Chemotherapy in Murine Breast Cancer Model through Inhibition of MDSC Related Galectin-3", pages: 1 - 67, XP009544389
"Doctoral Dissertation", 15 August 2011, NORTHWEST UNIVERSITY, CN, article LI, JIANJUN: "The Study on the Controlled Degradation of Citrus Pectic Polysaccharide and the Purification and Activity of Oligogalacturonic Acid Fragments", pages: 1 - 106, XP009544388
"Doctoral Dissertation", 1 May 2014, ZHEJIANG UNIVERSITY, CN, article SHEN, YANWEI: "The Synergistic Effect of Low Molecular Weight Citrus Pectin on Chemotherapy in Murine Breast Cancer Model through Inhibition of MDSC Related Galectin-3", pages: 1 - 67, XP009544389
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW CO., LTD. (CN)
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