Title:
HOMOPIPERAZINE ACETHYDRAZIDE DERIVATIVES, PREPARATION METHOD AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/102513
Kind Code:
A1
Abstract:
Disclosed are new homopiperazine acethydrazide derivatives of formula I or formula II, the definition of each symbol is shown as the description. The method for preparing said homopiperazine acethydrazide derivatives, the uses of said homopiperazine acethydrazide derivatives in preparation of medicines for treatment and/or prophylaxis of tumors and/or cancers, the pharmaceutical compositions comprising said homopiperazine acethydrazide derivatives are also disclosed. The present homopiperazine acethydrazide derivatives have effective antitumor activity, and especially they can be used for target therapy and/or prophylaxis of lung cancer, leukaemia, and liver cancer.
Inventors:
LIU XIANJUN (CN)
TAN MENGQUN (CN)
WANG DANDAN (CN)
TAN MENGQUN (CN)
WANG DANDAN (CN)
Application Number:
PCT/CN2010/000293
Publication Date:
September 16, 2010
Filing Date:
March 10, 2010
Export Citation:
Assignee:
SHENZHEN INST OF XIANGYA BIOME (CN)
LIU XIANJUN (CN)
TAN MENGQUN (CN)
WANG DANDAN (CN)
LIU XIANJUN (CN)
TAN MENGQUN (CN)
WANG DANDAN (CN)
International Classes:
C07D243/08; A61K31/55; A61P35/00
Domestic Patent References:
| WO2006128173A2 | 2006-11-30 |
Foreign References:
| CN101503394A | 2009-08-12 |
Other References:
MINORU IMAI ET AL.: "Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, 2004, pages 5407 - 5411
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (Vantone New World Plaza2 Fuchengmenwai Street, Beijing 7, CN)
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