Title:
HSV VIRUS VECTOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/020598
Kind Code:
A1
Abstract:
An HSV virus vector and the use thereof. ICP47 and ICP34.5 genes of the HSV virus vector are silenced, and the HSV virus vector carries the CCL19 gene. The HSV virus vector can continue to express chemotactic factor CCL19, thereby effectively inhibiting tumors.
Inventors:
ZHANG XUHUI (CN)
HE YULAN (CN)
HE LIANGLIANG (CN)
LIU QIUYAN (CN)
HUANG JUN (CN)
FENG CUIJUAN (CN)
QIU JIANJIAN (CN)
CHEN XIAOFENG (CN)
LI WENJIA (CN)
HE YULAN (CN)
HE LIANGLIANG (CN)
LIU QIUYAN (CN)
HUANG JUN (CN)
FENG CUIJUAN (CN)
QIU JIANJIAN (CN)
CHEN XIAOFENG (CN)
LI WENJIA (CN)
Application Number:
PCT/CN2022/113446
Publication Date:
February 23, 2023
Filing Date:
August 19, 2022
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C12N7/01; A61K38/20; C12N15/85
Foreign References:
| CN114717203A | 2022-07-08 | |||
| CN108570455A | 2018-09-25 | |||
| CN111635913A | 2020-09-08 | |||
| CN107354136A | 2017-11-17 |
Other References:
LIU B L; ROBINSON M; HAN Z-Q; BRANSTON R H; ENGLISH C; REAY P; MCGRATH Y; THOMAS S K; THORNTON M; BULLOCK P; LOVE C A; COFFIN R S: "ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 10, no. 4, 1 February 2003 (2003-02-01), GB , pages 292 - 303, XP037772970, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3301885
JUN LI, O'MALLEY MARK, SAMPATH PADMA, KALINSKI PAWEL, BARTLETT DAVID L., THORNE STEVE H.: "Expression of CCL19 from Oncolytic Vaccinia Enhances Immunotherapeutic Potential while Maintaining Oncolytic Activity", NEOPLASIA, NEOPLASIA PRESS, US, vol. 14, no. 12, 1 December 2012 (2012-12-01), US , pages 1115 - 1121, XP055330932, ISSN: 1476-5586, DOI: 10.1593/neo.121272
WANG YANG, JIN JING, WU ZHEN, HU SHENG, HU HAN, NING ZHIFENG, LI YANFEI, DONG YUTING, ZOU JIANWEN, MAO ZEYONG, SHI XIAOTAI, ZHENG : "Stability and anti-tumor effect of oncolytic herpes simplex virus type 2", ONCOTARGET, vol. 9, no. 37, 15 May 2018 (2018-05-15), pages 24672 - 24683, XP093037075, DOI: 10.18632/oncotarget.25122
YAHONG LONG, MI YANXIA; LI YUNCHUN: "Progess on Research of Herpes Simplex Virus Type 1 Mutants for Cancer Therapy", SHENGWU YIXUE GONGCHENGXUE ZAZHI = JOURNAL OF BIOMEDICAL ENGINEERING, SICHUAN DAXUE HUAXI YIYUAN, CN, vol. 25, no. 6, 1 December 2008 (2008-12-01), CN , pages 1446 - 1449, XP055887076, ISSN: 1001-5515
JUN LI, O'MALLEY MARK, SAMPATH PADMA, KALINSKI PAWEL, BARTLETT DAVID L., THORNE STEVE H.: "Expression of CCL19 from Oncolytic Vaccinia Enhances Immunotherapeutic Potential while Maintaining Oncolytic Activity", NEOPLASIA, NEOPLASIA PRESS, US, vol. 14, no. 12, 1 December 2012 (2012-12-01), US , pages 1115 - 1121, XP055330932, ISSN: 1476-5586, DOI: 10.1593/neo.121272
WANG YANG, JIN JING, WU ZHEN, HU SHENG, HU HAN, NING ZHIFENG, LI YANFEI, DONG YUTING, ZOU JIANWEN, MAO ZEYONG, SHI XIAOTAI, ZHENG : "Stability and anti-tumor effect of oncolytic herpes simplex virus type 2", ONCOTARGET, vol. 9, no. 37, 15 May 2018 (2018-05-15), pages 24672 - 24683, XP093037075, DOI: 10.18632/oncotarget.25122
YAHONG LONG, MI YANXIA; LI YUNCHUN: "Progess on Research of Herpes Simplex Virus Type 1 Mutants for Cancer Therapy", SHENGWU YIXUE GONGCHENGXUE ZAZHI = JOURNAL OF BIOMEDICAL ENGINEERING, SICHUAN DAXUE HUAXI YIYUAN, CN, vol. 25, no. 6, 1 December 2008 (2008-12-01), CN , pages 1446 - 1449, XP055887076, ISSN: 1001-5515
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