Title:
HUMAN ANTIBODY FC DOMAIN VARIANT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/085632
Kind Code:
A1
Abstract:
The present invention relates to a human antibody Fc domain variant and a use thereof and, more specifically, to a human antibody Fc domain variant and use thereof as an antibody-drug conjugate, wherein the human antibody Fc domain variant has proline (P) substituted for the 235th amino acid of the wild-type human antibody Fc domain and thus lacks or has substantially no binding affinity for human FcγRs and C1q, with the consequent deficiency of antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cell-mediated phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC).
Inventors:
JUNG SANG TAEK (KR)
KIM SU YEON (KR)
JO MI GYEONG (KR)
KIM SU YEON (KR)
JO MI GYEONG (KR)
Application Number:
PCT/KR2023/016105
Publication Date:
April 25, 2024
Filing Date:
October 18, 2023
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07K16/00; A61K39/00; A61P35/00; C07K16/32
Foreign References:
| KR100973564B1 | 2010-08-03 | |||
| US7138370B2 | 2006-11-21 | |||
| US20110021755A1 | 2011-01-27 | |||
| US8362210B2 | 2013-01-29 | |||
| US20170058030A1 | 2017-03-02 |
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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