Title:
HUMAN BETA-DEFENSIN-3
Document Type and Number:
WIPO Patent Application WO2002040512
Kind Code:
A3
Abstract:
The invention relates to a peptide, hBD-3 (human beta-defensin-3) and to derivatives and fragments thereof, in addition to a method for producing the same. The inventive peptides can be made available as medicaments and can be used to resist and combat pathogenic germs. They are particularly useful for treating bacterial diseases of the respiratory system, in particular for infections caused by Burkholderia cepacia and Pseudomonas aeroginosa and for treating cystic fibrosis. The inventive peptides can also be used to treat inflammatory diseases of the gastro-intestinal tract, urogenital tract and to treat septicaemia.
Inventors:
FORSSMANN WOLF-GEORG (DE)
KLUEVER ENNO (DE)
CONEJO-GARCIA JOSE-RAMON (DE)
ADERMANN KNUT (DE)
BALS ROBERT (DE)
MAEGERT HANS-JUERGEN (DE)
KLUEVER ENNO (DE)
CONEJO-GARCIA JOSE-RAMON (DE)
ADERMANN KNUT (DE)
BALS ROBERT (DE)
MAEGERT HANS-JUERGEN (DE)
Application Number:
PCT/EP2001/013174
Publication Date:
December 19, 2002
Filing Date:
November 14, 2001
Export Citation:
Assignee:
IPF PHARMACEUTICALS GMBH (DE)
FORSSMANN WOLF-GEORG (DE)
KLUEVER ENNO (DE)
CONEJO-GARCIA JOSE-RAMON (DE)
ADERMANN KNUT (DE)
BALS ROBERT (DE)
MAEGERT HANS-JUERGEN (DE)
FORSSMANN WOLF-GEORG (DE)
KLUEVER ENNO (DE)
CONEJO-GARCIA JOSE-RAMON (DE)
ADERMANN KNUT (DE)
BALS ROBERT (DE)
MAEGERT HANS-JUERGEN (DE)
International Classes:
C07K14/47; C12N15/12; A61K38/00; (IPC1-7): C07K14/47; A61K38/17; C07K1/00; C07K1/06; C07K1/16; C12N15/12; C12N15/63; C12Q1/04; C12Q1/68
Domestic Patent References:
| WO2001092309A2 | 2001-12-06 | |||
| WO2002004487A2 | 2002-01-17 | |||
| WO2002009738A1 | 2002-02-07 | |||
| WO1999013080A1 | 1999-03-18 | |||
| WO2000046245A2 | 2000-08-10 |
Other References:
HARDER J ET AL: "Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 23 FEB 2001, vol. 276, no. 8, 23 February 2001 (2001-02-23), pages 5707 - 5713, XP002206911, ISSN: 0021-9258
GARCÍA J R ET AL: "Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction.", CELL AND TISSUE RESEARCH. GERMANY NOV 2001, vol. 306, no. 2, November 2001 (2001-11-01), pages 257 - 264, XP002206910, ISSN: 0302-766X
ANDREU D ET AL: "Animal antimicrobial peptides: an overview.", BIOPOLYMERS. UNITED STATES 1998, vol. 47, no. 6, 1998, pages 415 - 433, XP000996625, ISSN: 0006-3525
COLE A M ET AL: "Human antimicrobial peptides: analysis and application.", BIOTECHNIQUES. UNITED STATES OCT 2000, vol. 29, no. 4, October 2000 (2000-10-01), pages 822 - 826, 828, 830 - 831, XP001093806, ISSN: 0736-6205
GARCÍA J R ET AL: "Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction.", CELL AND TISSUE RESEARCH. GERMANY NOV 2001, vol. 306, no. 2, November 2001 (2001-11-01), pages 257 - 264, XP002206910, ISSN: 0302-766X
ANDREU D ET AL: "Animal antimicrobial peptides: an overview.", BIOPOLYMERS. UNITED STATES 1998, vol. 47, no. 6, 1998, pages 415 - 433, XP000996625, ISSN: 0006-3525
COLE A M ET AL: "Human antimicrobial peptides: analysis and application.", BIOTECHNIQUES. UNITED STATES OCT 2000, vol. 29, no. 4, October 2000 (2000-10-01), pages 822 - 826, 828, 830 - 831, XP001093806, ISSN: 0736-6205
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