Title:
HUMAN EQUIVALENT MONOCLONAL ANTIBODIES ENGINEERED FROM NONHUMAN VARIABLE REGIONS
Document Type and Number:
WIPO Patent Application WO/2009/129538
Kind Code:
A3
Abstract:
The present invention is directed to the creation of human equivalent CDRs and antibodies containing them by a method of producing an antibody which specifically binds to an antigen.
Inventors:
BERNETT MATTHEW J (US)
MOORE GREGORY (US)
DESJARLAIS JOHN R (US)
MOORE GREGORY (US)
DESJARLAIS JOHN R (US)
Application Number:
PCT/US2009/041144
Publication Date:
July 01, 2010
Filing Date:
April 20, 2009
Export Citation:
Assignee:
XENCOR INC (US)
BERNETT MATTHEW J (US)
MOORE GREGORY (US)
DESJARLAIS JOHN R (US)
BERNETT MATTHEW J (US)
MOORE GREGORY (US)
DESJARLAIS JOHN R (US)
International Classes:
C07K16/22; C07K16/00; C07K16/28
Domestic Patent References:
| WO2005056759A2 | 2005-06-23 | |||
| WO2006020114A2 | 2006-02-23 | |||
| WO2003025019A1 | 2003-03-27 | |||
| WO2006135793A2 | 2006-12-21 | |||
| WO2008031056A2 | 2008-03-13 | |||
| WO2005079479A2 | 2005-09-01 | |||
| WO2005014653A2 | 2005-02-17 | |||
| WO2003050260A2 | 2003-06-19 | |||
| WO2005054273A2 | 2005-06-16 | |||
| WO2006105338A2 | 2006-10-05 |
Foreign References:
| US7297334B2 | 2007-11-20 |
Other References:
LAZAR ET AL: "A molecular immunology approach to antibody humanization and functional optimization", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 44, no. 8, 1 December 2006 (2006-12-01), pages 1986 - 1998, XP005792736, ISSN: 0161-5890
HOLT L J ET AL: "Domain antibodies: proteins for therapy", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 11, 1 November 2003 (2003-11-01), pages 484 - 490, XP004467495, ISSN: 0167-7799
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, 1 September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933
QUEEN C ET AL: "A HUMANIZED ANTIBODY THAT BINDS TO THE INTERLEUKIN 2 RECEPTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. (PNAS), NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 86, 1 December 1989 (1989-12-01), pages 10029 - 10033, XP002947922, ISSN: 0027-8424
PRESTA L G ET AL: "HUMANIZATION OF AN ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR MONOCLONAL ANTIBODY FOR THE THERAPY OF SOLID TUMORS AND OTHER DISORDERS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, vol. 57, 15 October 1997 (1997-10-15), pages 4593 - 4599, XP002926854, ISSN: 0008-5472
HOLT L J ET AL: "Domain antibodies: proteins for therapy", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 11, 1 November 2003 (2003-11-01), pages 484 - 490, XP004467495, ISSN: 0167-7799
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, 1 September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933
QUEEN C ET AL: "A HUMANIZED ANTIBODY THAT BINDS TO THE INTERLEUKIN 2 RECEPTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. (PNAS), NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 86, 1 December 1989 (1989-12-01), pages 10029 - 10033, XP002947922, ISSN: 0027-8424
PRESTA L G ET AL: "HUMANIZATION OF AN ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR MONOCLONAL ANTIBODY FOR THE THERAPY OF SOLID TUMORS AND OTHER DISORDERS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD., US, vol. 57, 15 October 1997 (1997-10-15), pages 4593 - 4599, XP002926854, ISSN: 0008-5472
Attorney, Agent or Firm:
SILVA, Robin, M. et al. (LLPOne Market Street, Spear Street Towe, San Francisco CA, US)
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