HUMAN EX VIVO IMMUNE SYSTEM

WIPO Patent Application WO2001036589

A9

The present invention provides cultured immune system cells and methods of producing same. The method comprises culturing stromal cells and hemopoietic stem cells or in a chamber having a scaffolding covered or surrounded with culture medium, wherein the scaffolding allows for hemopoietic stem cells and stromal cells to have cell to cell contacts in three dimensions. The subject immune system cells are useful for screening drugs which inhibit or stimulate the immune system. The subject immune system cells are also useful in treating diseases of the immune system.

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WU J H DAVID
MANTALARIS ATHANASSIOS

PCT/US2000/031747

July 04, 2002

November 17, 2000

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UNIV ROCHESTER (US)

G01N33/50; A61K48/00; A61P37/00; C07K16/00; C12M3/06; C12N5/02; C12N5/0789; C12N15/09; C12P21/08; C12Q1/68; G01N33/15; G01N33/569; (IPC1-7): A01N1/00; A01N63/00; A01N65/00; A61K39/395; C12M1/00; C12M1/12; C12N5/00; C07K16/00; C12P21/08

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