Title:
HUMAN INTERFERON-BETA VARIANT WITH DOUBLE MUTATION AND METHOD FOR IMPROVING STABILITY OF HUMAN INTERFERON-BETA VARIANT
Document Type and Number:
WIPO Patent Application WO/2021/221485
Kind Code:
A1
Abstract:
The present invention relates to a human interferon-beta variant with double mutation and a method for improving stability of a human interferon-beta variant and, more specifically, to a human interferon-beta variant including an amino acid sequence having serine substituted for the 17th amino acid cysteine of the human interferon-beta and threonine substituted for the 27th amino acid arginine of the human interferon-beta, and a method for improving stability of human interferon-beta R27T variant, the method comprising a step of substituting serine for the 17th amino acid serine in the human interferon-beta R27T variant in which threonine is substituted for the 27th amino acid arginine of human interferon-beta.
Inventors:
CHOI JUN YOUNG (KR)
KIM NA YOUNG (KR)
SON WON RAK (KR)
HONG SUNG HYUN (KR)
LEE YOUNG JIN (KR)
LEE SAE HYUNG (KR)
KIM NA YOUNG (KR)
SON WON RAK (KR)
HONG SUNG HYUN (KR)
LEE YOUNG JIN (KR)
LEE SAE HYUNG (KR)
Application Number:
PCT/KR2021/005487
Publication Date:
November 04, 2021
Filing Date:
April 29, 2021
Export Citation:
Assignee:
ABION INC (KR)
International Classes:
C07K1/113; A61K38/21; A61P25/00; A61P31/12; A61P35/00; C07K14/565; C07K14/715; C12N15/85
Domestic Patent References:
| WO1998028007A1 | 1998-07-02 |
Foreign References:
| KR100781666B1 | 2007-12-03 | |||
| KR20180038290A | 2018-04-16 | |||
| KR20160013513A | 2016-02-04 | |||
| US20090208454A1 | 2009-08-20 | |||
| KR20200052513A | 2020-05-15 | |||
| KR20200052913A | 2020-05-15 | |||
| KR100781666B1 | 2007-12-03 | |||
| US20120177603A1 | 2012-07-12 |
Other References:
ARDUINI, PROTEIN SCIENCE, vol. 8, 1999, pages 1867 - 1877
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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