Title:
HUMAN INTERLEUKIN-2 VARIANT OR DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/125743
Kind Code:
A1
Abstract:
Provided is a human interleukin-2 (IL-2) variant having one or more amino acid mutations or a derivative thereof. The IL-2 variant or derivative thereof has increased stability compared to wild-type IL-2 and improved properties as an immunotherapeutic agent. Also disclosed are an immunoconjugate and a pharmaceutical composition which comprise the human IL-2 variant or derivative thereof, a polynucleotide molecule encoding same, a vector, a host cell and a preparation method therefor, as well as the pharmaceutical uses of the IL-2 variant or derivative thereof and the immunoconjugate or pharmaceutical composition comprising the L-2 variant or derivative thereof.
Inventors:
CHEN LEI (CN)
HU QIYUE (CN)
GE HU (CN)
LIN YUAN (CN)
WANG HONGWEI (CN)
OU YANGCHAO (CN)
KONG XIANGLIN (CN)
LIAO CHENG (CN)
ZHANG LIANSHAN (CN)
HU QIYUE (CN)
GE HU (CN)
LIN YUAN (CN)
WANG HONGWEI (CN)
OU YANGCHAO (CN)
KONG XIANGLIN (CN)
LIAO CHENG (CN)
ZHANG LIANSHAN (CN)
Application Number:
PCT/CN2019/126901
Publication Date:
June 25, 2020
Filing Date:
December 20, 2019
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K14/55; A61K38/20; A61K47/60; A61K47/62; A61K47/68; A61P35/00; A61P37/00; C07K17/08; C07K19/00; C12N15/26; C12N15/63; C12P21/02
Domestic Patent References:
| WO2005007121A2 | 2005-01-27 | |||
| WO2012062228A2 | 2012-05-18 | |||
| WO2016014428A2 | 2016-01-28 | |||
| WO1999060128A1 | 1999-11-25 | |||
| WO2009135615A2 | 2009-11-12 | |||
| WO2017136818A2 | 2017-08-10 | |||
| WO2012107417A1 | 2012-08-16 |
Foreign References:
| CN103492411A | 2014-01-01 | |||
| CN1599867A | 2005-03-23 | |||
| CN201280017730A | 2012-02-07 | |||
| US8906356B2 | 2014-12-09 | |||
| US9732134B2 | 2017-08-15 | |||
| US7371371B2 | 2008-05-13 | |||
| US7514073B2 | 2009-04-07 | |||
| US8124066B2 | 2012-02-28 | |||
| US7803361B2 | 2010-09-28 |
Other References:
MATHER ET AL., ANNALS N.Y. ACAD SCI, vol. 383, 1982, pages 44 - 68
J. BIOL. CHEM, vol. 243, 1968, pages 3558
LILJEBLAD ET AL., GLYCO, vol. J17, 2000, pages 323 - 329
HEELEY, ENDOCR RES, vol. 28, 2002, pages 217 - 229
WATSON ET AL.: "Molecular Biology of the Gene", 1987, THE BENJAMIN/CUMMINGS PUB. CO., pages: 224
SADA ET AL., J. FERMENTATION BIOENGINEERING, vol. 71, 1991, pages 137 - 139
See also references of EP 3875475A4
J. BIOL. CHEM, vol. 243, 1968, pages 3558
LILJEBLAD ET AL., GLYCO, vol. J17, 2000, pages 323 - 329
HEELEY, ENDOCR RES, vol. 28, 2002, pages 217 - 229
WATSON ET AL.: "Molecular Biology of the Gene", 1987, THE BENJAMIN/CUMMINGS PUB. CO., pages: 224
SADA ET AL., J. FERMENTATION BIOENGINEERING, vol. 71, 1991, pages 137 - 139
See also references of EP 3875475A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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