Title:
HUMAN ANTIBODY–PRODUCING NON-HUMAN ANIMAL AND METHOD FOR PREPARING HUMAN ANTIBODIES USING SAME
Document Type and Number:
WIPO Patent Application WO/2018/079857
Kind Code:
A1
Abstract:
The present application provides: a non-human animal which is stably maintained in progeny and can produce human antibodies, and which is characterized by including a mouse artificial chromosome that contains a human antibody heavy chain gene or gene locus, and a human antibody κ light chain gene or gene locus and/or a human antibody λ light chain gene or gene locus, and in that at least two endogenous antibody genes or gene loci each corresponding to a human antibody gene or gene locus have been knocked out; a preparation method for the non-human animal; and a method for producing human antibodies using the non-human animal.
Inventors:
KAZUKI YASUHIRO (JP)
ABE SATOSHI (JP)
OSHIMURA MITSUO (JP)
ABE SATOSHI (JP)
OSHIMURA MITSUO (JP)
Application Number:
PCT/JP2017/039441
Publication Date:
May 03, 2018
Filing Date:
October 31, 2017
Export Citation:
Assignee:
NAT UNIV CORP TOTTORI UNIV (JP)
TRANS CHROMOSOMICS INC (JP)
TRANS CHROMOSOMICS INC (JP)
International Classes:
C12N15/00; A01K67/027; C12N15/09; C12P21/08
Domestic Patent References:
| WO2011083870A1 | 2011-07-14 | |||
| WO2011062206A1 | 2011-05-26 | |||
| WO2000010383A1 | 2000-03-02 | |||
| WO2007069666A1 | 2007-06-21 | |||
| WO1998037757A1 | 1998-09-03 |
Foreign References:
| JP2007312792A | 2007-12-06 | |||
| JP2008200042A | 2008-09-04 | |||
| JP2013090631A | 2013-05-16 | |||
| JP2016504012A | 2016-02-12 | |||
| JP4082740B2 | 2008-04-30 | |||
| JP3797974B2 | 2006-07-19 | |||
| JP5557217B2 | 2014-07-23 | |||
| JP2016213844A | 2016-12-15 | |||
| JP2011083870A | 2011-04-28 |
Other References:
TAKIGUCHI, MASATO ET AL.: "A Novel and Stable Mouse Artificial Chromosome Vector", ACS SYNTHETIC BIOLOGY, vol. 3, 2014, pages 903 - 914, XP055472980
M. BRUGGEMANN ET AL., ARC. IMMUNOL. THER. EXP., vol. 63, 2015, pages 101 - 108
M. J. EVANSM. H. KAUFMAN, NATURE, vol. 292, 1981, pages 154 - 156
J. A. THOMSON ET AL., SCIENCE, vol. 282, 1999, pages 1145 - 1147
J. A. THOMSON ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 92, 1995, pages 7844 - 7848
J. A. THOMSON ET AL., BIOL. REPROD., vol. 55, 1996, pages 254 - 259
J. A. THOMSONV. S. MARSHALL, CURR. TOP. DEV. BIOL., vol. 38, 1998, pages 133 - 165
K. TAKAHASHIS. YAMANAKA, CELL, vol. 126, 2006, pages 663 - 676
K. TAKAHASHI ET AL., CELL, vol. 131, 2007, pages 861 - 872
J. YU ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
DIEKEN ET AL., NATURE GENETICS, vol. 12, no. 1, 1996, pages 74 - 182
KOI ET AL., JPN. J. CANCER RES., vol. 80, 1973, pages 413 - 418
CRE/LOXP SYSTEMB. SAUER, METHODS OF ENZYMOLOGY, vol. 225, 1993, pages 890 - 900
M. NAKAGAWA ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 101 - 106
J. LIAO ET AL., CELL RES., vol. 18, 2008, pages 600 - 603
TAKAHASHI, K. ET AL., CELL, vol. 131, 2007, pages 861 - 872
M. JINEK ET AL., SCIENCE, vol. 337, 2012, pages 816 - 821
M. J. EVANSM. H. KAUFMAN, NATURE, vol. 292, no. 5819, 1981, pages 154 - 156
K. KAWAHARADA ET AL., WORLD J. STEM CELLS, vol. 7, no. 7, 2015, pages 1054 - 1063
W. LI ET AL., CELL STEM CELL, vol. 4, 2009, pages 16 - 19
S. HAMANAKA ET AL., PLOS ONE, vol. 6, 2011, pages e22008
T. SUZUKI ET AL., PLOS ONE, 2016
M. KATOH ET AL., BMC BIOTECHNOLOGY, vol. 10, 2010, pages 37
C. TSURUMAKI ET AL., J. MAMM. OVA RES., vol. 26, 2009, pages 86 - 93
MATSUBARASHUJUNSHA CO., LTD. ET AL.: "FISH experimental protocol", 1994
TOYAMAANDOKODANSHA, EXPERIMENTAL MANUAL FOR MONOCLONAL ANTIBODY, 1987
ANDOCHIBAKODANSHA, INTRODUCTION OF EXPERIMENT FOR MONOCLONAL ANTIBODY, 1991
ISHIKAWA: "Ultrasensitive Enzyme Immunoassays", 1993, GAKKAI SHUPPAN CENTER
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
A. DOYLEJ. B. GRIFFITHS: "Cell & Tissue Culture: Laboratory Procedures", 1996, JOHN WILEY & SONS LTD.
HIRABAYASHI ET AL., MOL. REPROD. DEV., vol. 77, no. 2, February 2010 (2010-02-01)
MATSUBARA ET AL.: "FISH experimental protocol", 1994, SHUJUNSHA CO., LTD.
"GenBank", Database accession no. NC_000022.11
PROC. NATL. ACAD. SCI., U.S.A., vol. 97, no. 2, 18 January 2000 (2000-01-18), pages 722 - 7
See also references of EP 3533867A4
M. BRUGGEMANN ET AL., ARC. IMMUNOL. THER. EXP., vol. 63, 2015, pages 101 - 108
M. J. EVANSM. H. KAUFMAN, NATURE, vol. 292, 1981, pages 154 - 156
J. A. THOMSON ET AL., SCIENCE, vol. 282, 1999, pages 1145 - 1147
J. A. THOMSON ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 92, 1995, pages 7844 - 7848
J. A. THOMSON ET AL., BIOL. REPROD., vol. 55, 1996, pages 254 - 259
J. A. THOMSONV. S. MARSHALL, CURR. TOP. DEV. BIOL., vol. 38, 1998, pages 133 - 165
K. TAKAHASHIS. YAMANAKA, CELL, vol. 126, 2006, pages 663 - 676
K. TAKAHASHI ET AL., CELL, vol. 131, 2007, pages 861 - 872
J. YU ET AL., SCIENCE, vol. 318, 2007, pages 1917 - 1920
DIEKEN ET AL., NATURE GENETICS, vol. 12, no. 1, 1996, pages 74 - 182
KOI ET AL., JPN. J. CANCER RES., vol. 80, 1973, pages 413 - 418
CRE/LOXP SYSTEMB. SAUER, METHODS OF ENZYMOLOGY, vol. 225, 1993, pages 890 - 900
M. NAKAGAWA ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 101 - 106
J. LIAO ET AL., CELL RES., vol. 18, 2008, pages 600 - 603
TAKAHASHI, K. ET AL., CELL, vol. 131, 2007, pages 861 - 872
M. JINEK ET AL., SCIENCE, vol. 337, 2012, pages 816 - 821
M. J. EVANSM. H. KAUFMAN, NATURE, vol. 292, no. 5819, 1981, pages 154 - 156
K. KAWAHARADA ET AL., WORLD J. STEM CELLS, vol. 7, no. 7, 2015, pages 1054 - 1063
W. LI ET AL., CELL STEM CELL, vol. 4, 2009, pages 16 - 19
S. HAMANAKA ET AL., PLOS ONE, vol. 6, 2011, pages e22008
T. SUZUKI ET AL., PLOS ONE, 2016
M. KATOH ET AL., BMC BIOTECHNOLOGY, vol. 10, 2010, pages 37
C. TSURUMAKI ET AL., J. MAMM. OVA RES., vol. 26, 2009, pages 86 - 93
MATSUBARASHUJUNSHA CO., LTD. ET AL.: "FISH experimental protocol", 1994
TOYAMAANDOKODANSHA, EXPERIMENTAL MANUAL FOR MONOCLONAL ANTIBODY, 1987
ANDOCHIBAKODANSHA, INTRODUCTION OF EXPERIMENT FOR MONOCLONAL ANTIBODY, 1991
ISHIKAWA: "Ultrasensitive Enzyme Immunoassays", 1993, GAKKAI SHUPPAN CENTER
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
A. DOYLEJ. B. GRIFFITHS: "Cell & Tissue Culture: Laboratory Procedures", 1996, JOHN WILEY & SONS LTD.
HIRABAYASHI ET AL., MOL. REPROD. DEV., vol. 77, no. 2, February 2010 (2010-02-01)
MATSUBARA ET AL.: "FISH experimental protocol", 1994, SHUJUNSHA CO., LTD.
"GenBank", Database accession no. NC_000022.11
PROC. NATL. ACAD. SCI., U.S.A., vol. 97, no. 2, 18 January 2000 (2000-01-18), pages 722 - 7
See also references of EP 3533867A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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