Title:
HUMAN NOSE INFERIOR NASAL CONCHA-DERIVED MESENCHYMAL STEM CELL-BASED, 3D BIOPRINTED CONSTRUCT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/203651
Kind Code:
A9
Abstract:
The present invention relates to a method for fabricating a human nose inferior nasal concha-derived mesenchymal stem cell-based, 3D bioprinted construct, and a use thereof. Conventional mesenchymal stem cells are accompanied by a severe pain in the acquirement procedure thereof, have a limitation to the time of acquirement, and require much time and cost and have a high risk of being contaminated during the cultivation thereof in a sufficient quantity. In contrast, human nose inferior nasal concha-derived mesenchymal stem cells have the advantage of being at a low risk of operation for the acquirement thereof and being able to be acquired in a sufficient amount anytime. In addition, a human nose inferior nasal concha-derived mesenchymal stem cell-based, 3D bioprinted construct is advantageous over conventional mesenchymal stem cell-based, 3D bioprinted constructs in that the former can survive and proliferate stably in vitro and/or in vivo and shows high osteogenic differentiation as well. Thanks to the advantages, human nose inferior nasal concha-derived mesenchymal stem cells allow the easy fabrication of 3D bioprinted constructs which are thus expected to make a great contribution to the practical use of cell therapy products.
Inventors:
KIM SUNG WON (KR)
LIM JUNG YEON (KR)
PARK SUN HWA (KR)
YOON BYEONG GON (KR)
CHO DONG-WOO (KR)
JANG JINAH (KR)
KIM SEOK WON (KR)
LIM JUNG YEON (KR)
PARK SUN HWA (KR)
YOON BYEONG GON (KR)
CHO DONG-WOO (KR)
JANG JINAH (KR)
KIM SEOK WON (KR)
Application Number:
PCT/KR2018/005068
Publication Date:
May 16, 2019
Filing Date:
May 02, 2018
Export Citation:
Assignee:
CATHOLIC UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C12N5/0775; A61K35/28; B29C64/106; B33Y80/00; B29K67/00
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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