Title:
HUMAN PROTEIN PHOSPHATASE 2C-LIKE ENZYME
Document Type and Number:
WIPO Patent Application WO2002097074
Kind Code:
A3
Abstract:
Reagents that regulate human protein phosphatase 2C-like enzyme and reagents which bind to human protein phosphatase 2C-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, CNS disorders, COPD, obesity, and diabetes.
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Inventors:
ZHU ZHIMIN (US)
Application Number:
PCT/EP2002/005874
Publication Date:
November 13, 2003
Filing Date:
May 29, 2002
Export Citation:
Assignee:
BAYER AG (DE)
ZHU ZHIMIN (US)
ZHU ZHIMIN (US)
International Classes:
C12N9/16; A61K38/00; (IPC1-7): C12N9/16; C12N5/10; C12N15/00; C12Q1/68; G01N33/50
Domestic Patent References:
| WO2002018565A2 | 2002-03-07 |
Other References:
DATABASE EMBL [online] 16 January 1997 (1997-01-16), LABES ET AL.: "Rat petrin", XP002224908, Database accession no. AAW04327
TRAVIS S M ET AL: "PP2Cgamma: a human protein phosphatase with a unique acidic domain", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 412, no. 3, 1 August 1997 (1997-08-01), pages 415 - 419, XP002085149, ISSN: 0014-5793
PRICE N E ET AL: "Brain protein serine/threonine phosphatases", CURRENT OPINION IN NEUROBIOLOGY, LONDON, GB, vol. 9, 1999, pages 336 - 342, XP002207990, ISSN: 0959-4388
CHING YICK PANG ET AL: "Specificity of different isoforms of protein phosphatase-2A and protein phosphatase-2C studied using site-directed mutagenesis of HMG-CoA reductase", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 411, no. 2-3, 1997, pages 265 - 268, XP002160001, ISSN: 0014-5793
MARLEY ANNA E ET AL: "Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C-alpha.", BIOCHEMICAL JOURNAL, vol. 320, no. 3, 1996, pages 801 - 806, XP002224907, ISSN: 0264-6021
BARFORD D: "Molecular mechanisms of the protein serine/threonine phosphatases", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 21, no. 11, 1 November 1996 (1996-11-01), pages 407 - 412, XP004071015, ISSN: 0968-0004
TRAVIS S M ET AL: "PP2Cgamma: a human protein phosphatase with a unique acidic domain", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 412, no. 3, 1 August 1997 (1997-08-01), pages 415 - 419, XP002085149, ISSN: 0014-5793
PRICE N E ET AL: "Brain protein serine/threonine phosphatases", CURRENT OPINION IN NEUROBIOLOGY, LONDON, GB, vol. 9, 1999, pages 336 - 342, XP002207990, ISSN: 0959-4388
CHING YICK PANG ET AL: "Specificity of different isoforms of protein phosphatase-2A and protein phosphatase-2C studied using site-directed mutagenesis of HMG-CoA reductase", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 411, no. 2-3, 1997, pages 265 - 268, XP002160001, ISSN: 0014-5793
MARLEY ANNA E ET AL: "Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C-alpha.", BIOCHEMICAL JOURNAL, vol. 320, no. 3, 1996, pages 801 - 806, XP002224907, ISSN: 0264-6021
BARFORD D: "Molecular mechanisms of the protein serine/threonine phosphatases", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 21, no. 11, 1 November 1996 (1996-11-01), pages 407 - 412, XP004071015, ISSN: 0968-0004
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