Title:
HUMANEERED ANTI-FACTOR B ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2013/177035
Kind Code:
A3
Abstract:
This invention relates to humaneered anti-factor B antibodies and antigen-binding fragments thereof with modified glycosylation patterns. The humaneered anti-factor B antibodies and antigen-binding fragments thereof are derived from murine monoclonal antibody 1379, which binds factor B in the third short consensus repeat ("SCR") domain and selectively inhibits activation of the alternative complement pathway by preventing formation of the C3bBb complex. The invention also relates to methods of treating diseases or disorders in which activation of the alternative complement pathway plays a role, and methods of selectively inhibiting activation of the alternative complement pathway in an individual in need thereof.
Inventors:
HUNTER JEFFREY W (US)
SHERIDAN DOUGLAS L (US)
SHERIDAN DOUGLAS L (US)
Application Number:
PCT/US2013/041811
Publication Date:
January 16, 2014
Filing Date:
May 20, 2013
Export Citation:
Assignee:
ALEXION PHARMA INC (US)
International Classes:
C07K16/36
Domestic Patent References:
| WO2009061910A1 | 2009-05-14 | |||
| WO2000021559A2 | 2000-04-20 |
Foreign References:
| US20080299114A1 | 2008-12-04 | |||
| US20090123469A1 | 2009-05-14 | |||
| US20050260198A1 | 2005-11-24 |
Other References:
See also references of EP 2855529A4
Attorney, Agent or Firm:
BIEKER-BRADY, Kristina (101 Federal Street15th Floo, Boston MA, US)
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