Title:
HUMANISED ANTIBODIES LABELLED WITH RADIONUCLIDES THAT EMIT β-RAYS
Document Type and Number:
WIPO Patent Application WO/2022/225006
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing anti-MUC5AC humanised antibodies labelled with radionuclides, said antibodies having excellent specificity for mucin subtype 5AC (MUC5AC) and excellent accumulation in tumours. The present invention provides a complex of a radionuclide and an antibody, wherein the radionuclide is a nuclide that emits β-rays, and the antibody is a humanised antibody which binds specifically to mucin subtype 5AC and which has a heavy-chain variable region comprising an amino acid sequence indicated by one of SEQ ID NOs 1-4 and a light-chain variable region comprising an amino acid sequence indicated by one of SEQ ID NOs 5-8.
Inventors:
YAMADA MASATO (JP)
TAKENAKA FUMIAKI (JP)
HARADA KOTARO (JP)
KOMURA MOMOKO (JP)
MATONO MITSUHIRO (JP)
OTSUKI KUMIKO (JP)
OCHIAI YASUSHI (JP)
MURAKAMI TAKAYUKI (JP)
TAKENAKA FUMIAKI (JP)
HARADA KOTARO (JP)
KOMURA MOMOKO (JP)
MATONO MITSUHIRO (JP)
OTSUKI KUMIKO (JP)
OCHIAI YASUSHI (JP)
MURAKAMI TAKAYUKI (JP)
Application Number:
PCT/JP2022/018413
Publication Date:
October 27, 2022
Filing Date:
April 21, 2022
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
SUMITOMO PHARMA CO LTD (JP)
SUMITOMO PHARMA CO LTD (JP)
International Classes:
C07K16/30; A61K39/395; A61K47/68; A61K51/02; A61K51/10; A61P35/00; A61P35/04; C07K16/46; C12N15/13
Domestic Patent References:
| WO2013157102A1 | 2013-10-24 | |||
| WO2021075544A1 | 2021-04-22 | |||
| WO2013157102A1 | 2013-10-24 | |||
| WO2013157105A1 | 2013-10-24 | |||
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| WO2018230257A1 | 2018-12-20 | |||
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Other References:
KEIGO ENDO, NAOYUKI WATANABE: "Methodology and clinical usefulness of radioimmunodiagnosis using RI-labeled monoclonal antibody", JAPANESE JOURNAL OF CLINICAL MEDICINE,, vol. 54, no. 6, 1 June 1996 (1996-06-01), JP , pages 138 - 143, XP009540477, ISSN: 0047-1852
JAPANESE JOURNAL OF CANCER RESEARCH, vol. 87, 1996, pages 977 - 984
JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 64, 2006, pages 274 - 278
JAPANESE JOURNAL OF CANCER RESEARCH, vol. 90, 1999, pages 1179 - 1186
PLOS ONE, vol. 6, no. e29180, December 2011 (2011-12-01), pages 1 - 10
JAPANESE JOURNAL OF CANCER RESEARCH, vol. 87, 1996, pages 977 - 984
JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 64, 2006, pages 274 - 278
JAPANESE JOURNAL OF CANCER RESEARCH, vol. 90, 1999, pages 1179 - 1186
PLOS ONE, vol. 6, no. e29180, December 2011 (2011-12-01), pages 1 - 10
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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