Title:
HUMANIZED PCRV ANTIBODY HAVING ANTI-PSEUDOMONAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2010/104052
Kind Code:
A1
Abstract:
Disclosed are a humanized monoclonal antibody against PcrV or a part thereof and a pharmaceutical composition comprising the humanized monoclonal antibody or a part thereof as an active ingredient, both of which are effective means for the treatment of infectious diseases, particularly infectious diseases induced by Pseudomonas aeruginosa. Specifically, the humanized monoclonal antibody has an excellent inhibitory activity on the cytotoxicity of Pseudomonas aeruginosa against a target cell. The humanized monoclonal antibody has a high affinity for PcrV.
Inventors:
YAMANO YOSHINORI (JP)
NUMATA YOSHITO (JP)
SATO TAKAFUMI (JP)
TSUJI TOSHINAGA (JP)
KAWAMOTO KEIKO (JP)
NUMATA YOSHITO (JP)
SATO TAKAFUMI (JP)
TSUJI TOSHINAGA (JP)
KAWAMOTO KEIKO (JP)
Application Number:
PCT/JP2010/053828
Publication Date:
September 16, 2010
Filing Date:
March 09, 2010
Export Citation:
Assignee:
SHIONOGI & CO (JP)
YAMANO YOSHINORI (JP)
NUMATA YOSHITO (JP)
SATO TAKAFUMI (JP)
TSUJI TOSHINAGA (JP)
KAWAMOTO KEIKO (JP)
YAMANO YOSHINORI (JP)
NUMATA YOSHITO (JP)
SATO TAKAFUMI (JP)
TSUJI TOSHINAGA (JP)
KAWAMOTO KEIKO (JP)
International Classes:
C12N15/09; A61K39/395; A61P31/04; C07K16/12
Domestic Patent References:
| WO2009073631A2 | 2009-06-11 | |||
| WO2009088032A1 | 2009-07-16 |
Foreign References:
| JP2007533304A | 2007-11-22 | |||
| JP2005500250A | 2005-01-06 |
Other References:
BAER M. ET AL.: "An Engineered Human Antibody Fab Fragment Specific for pseudomonas aeruginosa PcrV Antigen Has Potent Antibacterial Activity", INFECTION AND IMMUNITY, vol. 77, no. 3, March 2009 (2009-03-01), pages 1083 - 1090, XP002581947
DATABASE DATABASE DDBJ/EMBL/GENBAN [online] 19 November 1997 (1997-11-19), YAHR T.L. ET AL.: "DEFINITION: Pseudomonas aeruginosa PcrG (pcrG), PcrV (pcrV), PcrH, PopB(popB) and PopD(popD) genes, complete cds", XP008164986, Database accession no. AFO10149
FAURE K ET AL.: "Effects of monoclonal anti- PcrV antibody on Pseudomonas aeruginosa-induced acute lung injury in a rat model, J. Immune Based Ther.", VACCINES, vol. 1, no. 2, 2003, XP021008582
YAHR T.L. ET AL.: "Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon.", J. BACTERIOL., vol. 179, 1997, pages 7165 - 7168, XP000915058
See also references of EP 2407537A4
DATABASE DATABASE DDBJ/EMBL/GENBAN [online] 19 November 1997 (1997-11-19), YAHR T.L. ET AL.: "DEFINITION: Pseudomonas aeruginosa PcrG (pcrG), PcrV (pcrV), PcrH, PopB(popB) and PopD(popD) genes, complete cds", XP008164986, Database accession no. AFO10149
FAURE K ET AL.: "Effects of monoclonal anti- PcrV antibody on Pseudomonas aeruginosa-induced acute lung injury in a rat model, J. Immune Based Ther.", VACCINES, vol. 1, no. 2, 2003, XP021008582
YAHR T.L. ET AL.: "Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon.", J. BACTERIOL., vol. 179, 1997, pages 7165 - 7168, XP000915058
See also references of EP 2407537A4
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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