HYBRID ANTIBODIES AND USES THEREOF - MILLENNIUM PHARM INC

Title:

HYBRID ANTIBODIES AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO2002062850

Kind Code:

A3

Abstract:

Methods of providing hybrid antibodies having improved assembly characteristics are disclosed. Accordingly, the present invention provides hybrid antibodies, antigen binding fragments thereof, which include a chimeric immunoglobulin heavy chain and a humanized or CDR-grafted immunoglobulin light chain, pharmaceutical compositions thereof, as well as nucleic acids encoding the aforesaid antibodies, host cells and vectors containing such nucleic acids. Therapeutic and diagnostic uses of such hybrid antibodies molecules thereof are also disclosed.

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Inventors:

O'KEEFE THERESA
RAO PAT

Application Number:

PCT/US2002/003925

Publication Date:

February 20, 2003

Filing Date:

January 30, 2002

Export Citation:

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Assignee:

MILLENNIUM PHARM INC (US)

International Classes:

C07K16/00; C12N15/13; (IPC1-7): C07K16/00; A61K39/395; C07K16/28; C12N15/13; G01N33/577

Domestic Patent References:

WO2000005268A1

2000-02-03

Foreign References:

US6160099A	2000-12-12
US6180370B1	2001-01-30

Other References:

LEWIS A P ET AL: "GENERATION OF HUMANIZED MONOCLONAL ANTIBODIES BY BEST FIT FRAMEWORK SELECTION AND RECOMBINANT POLYMERASE CHAIN REACTION", THE YEAR IN IMMUNOLOGY, KARGER, BASEL, CH, vol. 7, 1993, pages 110 - 118, XP000564651
WINTER G ET AL: "HUMANIZED ANTIBODIES", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 14, no. 6, 1996, pages 243 - 246, XP001005438, ISSN: 0167-4919
LITTLE M ET AL: "Of mice and men: hybridoma and recombinant antibodies", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 8, 1 August 2000 (2000-08-01), pages 364 - 370, XP004215163, ISSN: 0167-5699

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