Title:
Hybrid plasminogen activators
Document Type and Number:
WIPO Patent Application WO1991019793
Kind Code:
A3
Abstract:
A hybrid fibrinolytic enzyme, its preparation, pharmaceutical compositions containing it and its use in the treatment of thromboembolic diseases, in particular acute myocardial infarction.
Inventors:
ROBINSON JEFFERY HUGH (GB)
Application Number:
PCT/GB1991/000945
Publication Date:
January 23, 1992
Filing Date:
June 12, 1991
Export Citation:
Assignee:
BEECHAM GROUP PLC (GB)
ROBINSON JEFFERY HUGH (GB)
ROBINSON JEFFERY HUGH (GB)
International Classes:
A61K38/46; A61P7/02; A61K38/48; C12N9/64; C12N9/68; C12N9/72; C12N15/09; C12N15/58; A61K38/00; (IPC1-7): C12N15/58; C12N9/72; A61K37/54
Foreign References:
| EP0297882A2 | 1989-01-04 | |||
| EP0009879A1 | 1980-04-16 | |||
| EP0155387A2 | 1985-09-25 |
Other References:
Thrombosis Research, volume 47, no. 6, 15 September 1987, Pergamon Journals Ltd (US) J. Stürzebecher et al.: "Stable acyl-derivatives of tissue-type plasminogen activator", pages 699-703, see table 1; page 701, last sentence - page 702, paragraph 2
The Biochemical Journal, volume 247, 1987, (GB) R. Cassels et al.: "The interaction of streptokinase-plasminogen activator complex, tissue-type plasminogen activator, urokinase and their acylated derivatives with fibrin and cyanogen bromide digest of fibrinogen", pages 395-400, see abstract; table 2
The Biochemical Journal, volume 247, 1987, (GB) R. Cassels et al.: "The interaction of streptokinase-plasminogen activator complex, tissue-type plasminogen activator, urokinase and their acylated derivatives with fibrin and cyanogen bromide digest of fibrinogen", pages 395-400, see abstract; table 2
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