Title:
HYDRAZONE DERIVATIVES AND USE THEREOF IN MEDICINES
Document Type and Number:
WIPO Patent Application WO/2002/048096
Kind Code:
A1
Abstract:
Medicines containing compounds of the general formula (I): (I) [wherein R?1¿ is hydrogen or lower alkyl; and A is morpholino or a group of the general formula (II): (II) (wherein B is hydroxylated lower alkyl, carbamoyl, or glycyl whose amino group may be substituted)]. The compounds have potent inhibitory activity against cysteine proteases, particularly calpain, and proper water solubility for the use in medicines.
Inventors:
NAKAMURA MASAYUKI (JP)
INOUE JUN (JP)
INOUE JUN (JP)
Application Number:
PCT/JP2001/010667
Publication Date:
June 20, 2002
Filing Date:
December 06, 2001
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
NAKAMURA MASAYUKI (JP)
INOUE JUN (JP)
NAKAMURA MASAYUKI (JP)
INOUE JUN (JP)
International Classes:
A61K31/18; A61K31/5375; A61P9/10; A61P19/10; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P37/00; A61P43/00; C07C311/19; C07D295/30; (IPC1-7): C07C311/19; A61K31/18; A61K31/5375; A61P9/10; A61P19/10; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P37/00; A61P43/00; C07D295/28
Foreign References:
| EP0771565A2 | 1997-05-07 | |||
| EP0810221A1 | 1997-12-03 |
Attorney, Agent or Firm:
Matsuda, Reiko (LTD. Intellectual Property 5-8 Hiranomachi 2-chom, Chuo-ku Osaka-shi Osaka, JP)
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