Title:
HYDROGEN PEROXIDE RESISTANCE-IMPARTING GENE AND METHOD FOR USING SAME
Document Type and Number:
WIPO Patent Application WO/2012/121150
Kind Code:
A1
Abstract:
Provided is a gene that is useful for imparting hydrogen peroxide resistance to a microorganism. Also provided is a method for using the same. The hydrogen peroxide resistance-imparting gene encodes a protein selected from the following (a) through (c): (a) a protein formed from an amino acid sequence represented by Sequence No. 2, (b) a protein having hydrogen peroxide resistance-imparting capability formed from an amino acid sequence wherein one or more amino acids have been deleted, substituted or added in the amino acid sequence of (a), and (c) a protein having hydrogen peroxide resistance-imparting capability formed from an amino acid sequence that has 85% or greater identity with the amino acid sequence of (a).
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Inventors:
SERATA MASAKI (JP)
KIWAKI MAYUMI (JP)
IINO TOHRU (JP)
KIWAKI MAYUMI (JP)
IINO TOHRU (JP)
Application Number:
PCT/JP2012/055401
Publication Date:
September 13, 2012
Filing Date:
March 02, 2012
Export Citation:
Assignee:
YAKULT HONSHA KK (JP)
SERATA MASAKI (JP)
KIWAKI MAYUMI (JP)
IINO TOHRU (JP)
SERATA MASAKI (JP)
KIWAKI MAYUMI (JP)
IINO TOHRU (JP)
International Classes:
A23L1/30; C12N15/09; A61K35/74; A61K35/747; A61P39/06; C12M1/00; C12N1/21; C12Q1/68
Domestic Patent References:
| WO2009150856A1 | 2009-12-17 | |||
| WO2009150856A1 | 2009-12-17 |
Foreign References:
| JP2001327292A | 2001-11-27 |
Other References:
DATABASE GENBANK [online] 9 May 2010 (2010-05-09), "Definition: Lactobacillus casei BL23 complete genome, strain BL23", XP003030171, Database accession no. FM177140.1
MASAKI SERATA ET AL.: "Lactobacillus casei YIT 9029 (Shirota-kabu) ni Okeru Sanso Kasanka Suiso Stress Oto no Kaiseki", JOURNAL OF JAPAN SOCIETY FOR LACTIC ACID BACTERIA, vol. 19, no. 2, 15 June 2008 (2008-06-15), pages 122, XP008171086
TOMOYUKI SAKO ET AL.: "Genetical and reverse- genetical analyses of functions from Lactobacillus casei strain Shirota in post- genomic era", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR BIOTECHNOLOGY, vol. 58, 3 August 2006 (2006-08-03), JAPAN, pages 77, XP008170945
LEE J ET AL.: "Resistance of Lactobacillus casei KCTC3260 to reactive oxygen species(ROS):role for a metal ion chelating effect", JOURNAL OF FOOD SCIENCE, vol. 70, no. 8, 2005, pages M388 - M391, XP055125273
TAKASHI SATO ET AL.: "Genome Analysis of Lactic Acid Bacteria and Bifidobacteria : Genome Analysis of Lactobacillus casei and Bifidobacterium breve", JOURNAL OF INTESTINAL MICROBIOLOGY, vol. 18, 2004, pages 135 - 140, XP008170959
ROCHAT T ET AL.: "Production of a heterologous nonheme catalase by Lactobacillus casei: an efficient tool for removal of H202 and protection of Lactobacillus bulgaricus from oxidative stress in milk", APPL. ENVIRON. MICROBIOL., vol. 72, no. 8, 2006, pages 5143 - 5149, XP055125275
MASAKI SERATA ET AL.: "Lactobacillus casei YIT 9029 (Shirota-kabu) no Shinki Kasanka Suiso Taisei Idenshi no Kino Kaiseki", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY 2011 NENDO TAIKAI KOEN YOSHISHU, 5 March 2011 (2011-03-05), pages 108, XP008169197
L. MARIELA SERRANO ET AL., MICROBIAL CELL FACTORIES, vol. 6, 2007, pages 29
EDSON R. ROCHA ET AL., J. BACTERIOL., vol. 189, 2007, pages 8015 - 8023
KARIN VIDO ET AL., J. BACTERIOL., vol. 187, 2005, pages 601 - 610
LIPMAN, D. J.; PEARSON, W. R.: "Rapid and sensitive protein similarity searches", SCIENCE, vol. 227, 1985, pages 1435 - 1441, XP000941106, DOI: doi:10.1126/science.2983426
SAMBROOK ET AL.: "Molecular Cloning - a Laboratory manual", 1989
YASUDA ET AL., APPL. ENVIRON. MICROBIOL., vol. 74, 2008, pages 4746 - 4755
"BIOXYTECH H202-560", FUNAKOSHI CORPORATION
HALLIWELL, B.; J. M. GUTTERIDGE: "Formation of a thiobarbituric acid reactive substance from deoxyribose in the presence of iron salts", FEBS LETT., vol. 128, 1981, pages 347 - 352, XP025597169, DOI: doi:10.1016/0014-5793(81)80114-7
YAMAMOTO, Y.; L. B. POOLE; R. R. HANTGAN; Y. KAMIO: "An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro", J. BACTERIOL., vol. 184, 2002, pages 2931 - 2939
KIWAKI ET AL., BIOSCI. MICROFLORA, vol. 20, 2002, pages 121 - 129
MASAKI SERATA ET AL.: "Lactobacillus casei YIT 9029 (Shirota-kabu) ni Okeru Sanso Kasanka Suiso Stress Oto no Kaiseki", JOURNAL OF JAPAN SOCIETY FOR LACTIC ACID BACTERIA, vol. 19, no. 2, 15 June 2008 (2008-06-15), pages 122, XP008171086
TOMOYUKI SAKO ET AL.: "Genetical and reverse- genetical analyses of functions from Lactobacillus casei strain Shirota in post- genomic era", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR BIOTECHNOLOGY, vol. 58, 3 August 2006 (2006-08-03), JAPAN, pages 77, XP008170945
LEE J ET AL.: "Resistance of Lactobacillus casei KCTC3260 to reactive oxygen species(ROS):role for a metal ion chelating effect", JOURNAL OF FOOD SCIENCE, vol. 70, no. 8, 2005, pages M388 - M391, XP055125273
TAKASHI SATO ET AL.: "Genome Analysis of Lactic Acid Bacteria and Bifidobacteria : Genome Analysis of Lactobacillus casei and Bifidobacterium breve", JOURNAL OF INTESTINAL MICROBIOLOGY, vol. 18, 2004, pages 135 - 140, XP008170959
ROCHAT T ET AL.: "Production of a heterologous nonheme catalase by Lactobacillus casei: an efficient tool for removal of H202 and protection of Lactobacillus bulgaricus from oxidative stress in milk", APPL. ENVIRON. MICROBIOL., vol. 72, no. 8, 2006, pages 5143 - 5149, XP055125275
MASAKI SERATA ET AL.: "Lactobacillus casei YIT 9029 (Shirota-kabu) no Shinki Kasanka Suiso Taisei Idenshi no Kino Kaiseki", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY 2011 NENDO TAIKAI KOEN YOSHISHU, 5 March 2011 (2011-03-05), pages 108, XP008169197
L. MARIELA SERRANO ET AL., MICROBIAL CELL FACTORIES, vol. 6, 2007, pages 29
EDSON R. ROCHA ET AL., J. BACTERIOL., vol. 189, 2007, pages 8015 - 8023
KARIN VIDO ET AL., J. BACTERIOL., vol. 187, 2005, pages 601 - 610
LIPMAN, D. J.; PEARSON, W. R.: "Rapid and sensitive protein similarity searches", SCIENCE, vol. 227, 1985, pages 1435 - 1441, XP000941106, DOI: doi:10.1126/science.2983426
SAMBROOK ET AL.: "Molecular Cloning - a Laboratory manual", 1989
YASUDA ET AL., APPL. ENVIRON. MICROBIOL., vol. 74, 2008, pages 4746 - 4755
"BIOXYTECH H202-560", FUNAKOSHI CORPORATION
HALLIWELL, B.; J. M. GUTTERIDGE: "Formation of a thiobarbituric acid reactive substance from deoxyribose in the presence of iron salts", FEBS LETT., vol. 128, 1981, pages 347 - 352, XP025597169, DOI: doi:10.1016/0014-5793(81)80114-7
YAMAMOTO, Y.; L. B. POOLE; R. R. HANTGAN; Y. KAMIO: "An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro", J. BACTERIOL., vol. 184, 2002, pages 2931 - 2939
KIWAKI ET AL., BIOSCI. MICROFLORA, vol. 20, 2002, pages 121 - 129
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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