Title:
HYDROPHOBINS AS SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS
Document Type and Number:
WIPO Patent Application WO/2010/060811
Kind Code:
A3
Abstract:
The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e. g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.
Inventors:
BUTHE ANDREAS (DE)
HAFNER ANDREAS (CH)
KAUFMANN FRANZ (DE)
GABOR ESTHER (DE)
MEURER GUIDO (DE)
ECK JUERGEN (DE)
BRADLEY GORDON (CH)
HAFNER ANDREAS (CH)
KAUFMANN FRANZ (DE)
GABOR ESTHER (DE)
MEURER GUIDO (DE)
ECK JUERGEN (DE)
BRADLEY GORDON (CH)
Application Number:
PCT/EP2009/065100
Publication Date:
October 21, 2010
Filing Date:
November 13, 2009
Export Citation:
Assignee:
BASF SE (DE)
BUTHE ANDREAS (DE)
HAFNER ANDREAS (CH)
KAUFMANN FRANZ (DE)
GABOR ESTHER (DE)
MEURER GUIDO (DE)
ECK JUERGEN (DE)
BRADLEY GORDON (CH)
BUTHE ANDREAS (DE)
HAFNER ANDREAS (CH)
KAUFMANN FRANZ (DE)
GABOR ESTHER (DE)
MEURER GUIDO (DE)
ECK JUERGEN (DE)
BRADLEY GORDON (CH)
International Classes:
A61K9/20; A61K9/00; A61K9/28; C07K14/37
Domestic Patent References:
| WO2004000880A1 | 2003-12-31 | |||
| WO2000071079A2 | 2000-11-30 | |||
| WO2008051101A1 | 2008-05-02 | |||
| WO2006023795A2 | 2006-03-02 |
Foreign References:
| EP1350507A1 | 2003-10-08 |
Other References:
LUMSDON S O ET AL: "Adsorption of hydrophobin proteins at hydrophobic and hydrophilic interfaces", COLLOIDS AND SURFACES. B, BIOINTERFACES, ELSEVIER, AMSTERDAM, NL, vol. 44, no. 4, 1 September 2005 (2005-09-01), pages 172 - 178, XP025316033, ISSN: 0927-7765, [retrieved on 20050901]
HAAS JIMOH AKANBI M ET AL: "Use of hydrophobins in formulation of water insoluble drugs for oral administration", COLLOIDS AND SURFACES. B, BIOINTERFACES, ELSEVIER, AMSTERDAM, NL, vol. 75, no. 2, 1 February 2010 (2010-02-01), pages 526 - 531, XP026785559, ISSN: 0927-7765, [retrieved on 20090926]
COX A R ET AL: "Exceptional stability of food foams using class II hydrophobin HFBII", FOOD HYDROCOLLOIDS, ELSEVIER, vol. 23, no. 2, 1 March 2009 (2009-03-01), pages 366 - 376, XP025405329, ISSN: 0268-005X, [retrieved on 20080307]
HAAS JIMOH AKANBI M ET AL: "Use of hydrophobins in formulation of water insoluble drugs for oral administration", COLLOIDS AND SURFACES. B, BIOINTERFACES, ELSEVIER, AMSTERDAM, NL, vol. 75, no. 2, 1 February 2010 (2010-02-01), pages 526 - 531, XP026785559, ISSN: 0927-7765, [retrieved on 20090926]
COX A R ET AL: "Exceptional stability of food foams using class II hydrophobin HFBII", FOOD HYDROCOLLOIDS, ELSEVIER, vol. 23, no. 2, 1 March 2009 (2009-03-01), pages 366 - 376, XP025405329, ISSN: 0268-005X, [retrieved on 20080307]
Attorney, Agent or Firm:
BASF SE (P.O. Box, Basel, CH)
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