Title:
HYDROXAMIC ACID DERIVATIVE BASED ON AROMATIC SULFONAMIDE
Document Type and Number:
WIPO Patent Application WO/1993/012075
Kind Code:
A1
Abstract:
A novel hydroxamic acid derivative containing a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient, which has activities of inhibiting cell growth, vascularization, etc.. It has activities of inhibiting hemangioendothelial cell growth and the development of a lymphocyte adhesion factor, and detransformation by ras gene, thus inhibiting cell growth and being efficacious against inflammation and tumor.
Inventors:
OHTANI MITSUAKI (JP)
ARITA HITOSHI (JP)
SUGITA KENJI (JP)
MATSUURA TAKAHARU (JP)
SHIRAHASE KAZUHIRO (JP)
ARITA HITOSHI (JP)
SUGITA KENJI (JP)
MATSUURA TAKAHARU (JP)
SHIRAHASE KAZUHIRO (JP)
Application Number:
PCT/JP1992/001593
Publication Date:
June 24, 1993
Filing Date:
December 07, 1992
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07C59/64; C07C259/06; C07C271/28; C07C311/08; C07C311/19; C07C311/21; C07C311/29; C07D209/18; (IPC1-7): A61K31/16; A61K31/40; C07C259/06; C07C311/08; C07C311/21; C07D209/18
Other References:
Chemical and Pharmaceutical Bulletin, Vol. 31, No. 8, (1983), KUNIYOSHI TANAKA et al., "Syntheses and Anti-Inflamatory and Analgesic Activities of Hydroxamic Acid and Acid Hydrazides", p. 2810-2819.
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