Title:
HYDROXAMIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1993/009090
Kind Code:
A1
Abstract:
A compound represented by general formula (I), a pharmaceutical composition containing same, a process for the production thereof, and an intermediate therefor. In formula (I) R1 represents lower alkyl which may be substituted by a substituent selected from the group consisting of mercapto, lower alkylthio, arylthio and lower acylthio; R2, R3 and R4 may be the same or different from one another and each represents lower alkyl; X represents oxygen or sulfur; and Y represents a single bond or lower alkylene. The compound (I) has a matrix metalloprotease inhibitory activity and is useful for preventing and treating diseases caused by the progress of connective tissue breakage.
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Inventors:
ISOMURA YASUO (JP)
AKAMATSU SEIJIRO (JP)
YODEN TORU (JP)
KUDO MASAFUMI (JP)
SUGA AKIRA (JP)
AKAMATSU SEIJIRO (JP)
YODEN TORU (JP)
KUDO MASAFUMI (JP)
SUGA AKIRA (JP)
Application Number:
PCT/JP1992/001421
Publication Date:
May 13, 1993
Filing Date:
November 02, 1992
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
International Classes:
A61K31/165; A61K31/19; A61K31/215; A61K31/265; A61P1/02; A61P27/02; A61P29/00; A61P43/00; C07C237/22; C07C259/06; C07C323/57; C07C323/60; C07C327/30; C07C327/32; C07C327/34; (IPC1-7): A61K31/16; A61K31/255; C07C259/06; C07C323/22; C07C327/32
Foreign References:
| JPH04149170A | 1992-05-22 | |||
| US4599361A | 1986-07-08 | |||
| EP0214639A2 | 1987-03-18 |
Other References:
See also references of EP 0613883A4
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