Title:
HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS
Document Type and Number:
WIPO Patent Application WO2004022558
Kind Code:
A3
Abstract:
The present invention is directed to novel hydroxy alkyl substituted 1, 3, 8-triazaspiro[4.5]decan-4-one derivatives of the general formula: wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.
Inventors:
BATTISTA KATHLEEN (US)
BIGNAN GILLES (US)
CONNOLLY PETER J (US)
REITZ ALLEN B (US)
MORGAN ROSS TINA (US)
SCOTT MALCOLM (US)
MIDDLETON STEVE A (US)
ORSINI MICHAEL (US)
BIGNAN GILLES (US)
CONNOLLY PETER J (US)
REITZ ALLEN B (US)
MORGAN ROSS TINA (US)
SCOTT MALCOLM (US)
MIDDLETON STEVE A (US)
ORSINI MICHAEL (US)
Application Number:
PCT/US2003/027956
Publication Date:
May 21, 2004
Filing Date:
September 05, 2003
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
BATTISTA KATHLEEN (US)
BIGNAN GILLES (US)
CONNOLLY PETER J (US)
REITZ ALLEN B (US)
MORGAN ROSS TINA (US)
SCOTT MALCOLM (US)
MIDDLETON STEVE A (US)
ORSINI MICHAEL (US)
BATTISTA KATHLEEN (US)
BIGNAN GILLES (US)
CONNOLLY PETER J (US)
REITZ ALLEN B (US)
MORGAN ROSS TINA (US)
SCOTT MALCOLM (US)
MIDDLETON STEVE A (US)
ORSINI MICHAEL (US)
International Classes:
A61P25/00; C07D471/10; (IPC1-7): C07D471/10; A61K31/438; A61P25/00
Domestic Patent References:
| WO2000006545A1 | 2000-02-10 | |||
| WO2001007050A1 | 2001-02-01 | |||
| WO2001036418A1 | 2001-05-25 | |||
| WO1999059997A1 | 1999-11-25 | |||
| WO2001039723A2 | 2001-06-07 | |||
| WO2001094346A1 | 2001-12-13 | |||
| WO2002083673A1 | 2002-10-24 |
Foreign References:
| EP0997464A1 | 2000-05-03 | |||
| EP0921125A1 | 1999-06-09 | |||
| EP0856514A1 | 1998-08-05 | |||
| US4329353A | 1982-05-11 |
Other References:
DATABASE WPI Section Ch Week 200153, Derwent World Patents Index; Class B02, AN 2001-488618, XP002269085
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