Title:
HYDROXYSTYRENE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1988/007035
Kind Code:
A1
Abstract:
the invention is related to hydroxystyrene derivatives and salts thereof represented by general formula (I) (wherein R3 and R4 are bound to each other to form -CONH-CS-S-, (II), (III) or (IV) (wherein R6 is (V) (wherein X1 is H, halogen, methyl, ethyl, R7O- (wherein R7 is methyl or ethyl), nitro, aminosulfonyl, or amino and m1 is 1 or 2), pyridyl, furyl or thienyl and n1 is an integer of 0 to 3) when R1 and R2 each represents phenyl, benzyl or phenethyl or when R1 represents R5O- (wherein R5 is H, C1-C5 alkyl or benzyl) and R2 represents benzyl or PhSCH2; R3 represents cyano and R4 represents carbamoyl or they may be bound to each other to form -CO-Y-CH2CH2- (wherein Y is O or -NH) or (VI) when R1 and R2 each represents phenyl, benzyl or phenethyl or R1 represents R5O- (wherein R5 is as defined above) and R2 represents benzyl; or R3 and R4 are bound to each other to form (IV) (wherein n1 and R6 are as defined above) when R1 amd R2 each represents C1-C3 alkyl). They are useful as effective ingredients of anti-allergic agents, 5-lipoxygenase inhibitors, antibacterial agents, tyrosine kinase inhibitors, UV absorbers, and reverse transcriptase inhibitors, and are also useful as intermediates for many organic compounds.
Inventors:
SHIRAISHI TADAYOSHI (JP)
KAMEYAMA KEIJI (JP)
DOMOTO TAKESHI (JP)
IMAI NAOHIRO (JP)
SHIMADA YOSHIO (JP)
ARIKI YUTAKA (JP)
HOSOE KAZUNORI (JP)
KAWATSU MASAJI (JP)
KATSUMI IKUO (JP)
HIDAKA TAKAYOSHI (JP)
WATANABE KIYOSHI (JP)
KAMEYAMA KEIJI (JP)
DOMOTO TAKESHI (JP)
IMAI NAOHIRO (JP)
SHIMADA YOSHIO (JP)
ARIKI YUTAKA (JP)
HOSOE KAZUNORI (JP)
KAWATSU MASAJI (JP)
KATSUMI IKUO (JP)
HIDAKA TAKAYOSHI (JP)
WATANABE KIYOSHI (JP)
Application Number:
PCT/JP1988/000254
Publication Date:
September 22, 1988
Filing Date:
March 10, 1988
Export Citation:
Assignee:
KANEGAFUCHI CHEMICAL IND (JP)
International Classes:
A61K31/26; A61K31/27; A61K31/275; A61K31/34; A61K31/425; B21B31/02; B21B31/20; B21B33/00; B21B37/18; B21B37/72; C07C253/30; C07C255/34; C07C255/41; B21B31/16; C07C255/44; C07C255/53; C07D207/38; C07D209/34; C07D231/36; C07D277/20; C07D277/36; C07D277/54; C07D279/16; C07D307/32; C07D307/33; C07D307/52; C07D307/58; C07D417/12; C09K3/00; (IPC1-7): C07C121/75; C07C120/00; C07D207/38; C07D231/36; C07D277/36; C07D307/32; A61K7/42; A61K31/275; A61K31/34; A61K31/425; C09K3/00; C12N9/99
Foreign References:
| JPS62111962A | 1987-05-22 | |||
| JPH06239523A | 1994-08-30 | |||
| JPH06239522A | 1994-08-30 | |||
| JPH05879920A | ||||
| JPS49103929A | 1974-10-02 | |||
| JPS60237033A | 1985-11-25 | |||
| JPS60215636A | 1985-10-29 |
Other References:
See also references of EP 0304493A4
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