Title:
HYPERSULFATED DISACCHARIDES AND METHODS OF USING THE SAME FOR THE TREATMENT OF INFLAMMATIONS
Document Type and Number:
WIPO Patent Application WO2002083700
Kind Code:
A3
Abstract:
Provided are compounds and compositions thereof that are useful for treating inflammation, particularly pulmonary inflammations including asthma and asthma-related pathologies such as allergy. Also provided are methods for using such compounds and compositions of the invention to treat patients suffering from, or predisposed to develop inflammation.
More Like This:
| WO/1998/036747 | PHARMACEUTICAL COMPOSITION |
| WO/2002/085384 | LUBRICIOUS COATINGS FOR SUBSTRATES |
| JPS5221316 | PROCESS FOR PREPARING IMMUNO-GLOBULIN DERIVATIVES POSSESSING GLUTATHIO NE UNITS |
Inventors:
AHMED TAHIR
SMITH GREGORY A
SMITH GREGORY A
Application Number:
PCT/US2002/012256
Publication Date:
April 17, 2003
Filing Date:
April 16, 2002
Export Citation:
Assignee:
IVAX RESEARCH INC (US)
International Classes:
A61K9/08; A61K9/12; A61K9/20; A61K9/48; A61K9/72; A61K31/7024; A61P1/04; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P13/12; A61P17/00; A61P19/02; A61P27/14; A61P29/00; A61P37/08; C07H11/00; C07H11/04; C07H17/04; C08B37/00; C07B61/00; (IPC1-7): C07H17/04; C08B37/00
Domestic Patent References:
| WO1988005301A1 | 1988-07-28 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHAKLEE, PATRICK N. ET AL: "The disaccharides formed by deaminative cleavage of N-deacetylated glycosaminoglycans", XP002215189, retrieved from STN Database accession no. 105:79277 CA
BIENKOWSKI, MICHAEL J. ET AL: "Structural characterization of the oligosaccharides formed by depolymerization of heparin with nitrous acid", J. BIOL. CHEM. (1985), 260(1), 356-65, 1985, XP002215186
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HOPWOOD, JOHN J. ET AL: "Selective depolymerization of dermatan sulfate: production of radiolabelled substrates for.alpha.-L-iduronidase, sulfoiduronate sulfatase, and.beta.-D-glucuronidase", XP002215190, retrieved from STN Database accession no. 100:68630 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHAKLEE, PATRICK N. ET AL: "The disaccharides formed by deaminative cleavage of N-deacetylated glycosaminoglycans", XP002215191, retrieved from STN Database accession no. 105:79277 CA
EDGE, ALBERT S. B. ET AL: "Characterization of novel sequences containing 3-O-sulfated glucosamine i glomerular basement membrane heparan sulfate and localization of sulfated disaccharides to a peripheral domain", J. BIOL. CHEM. (1990), 265(26), 15874-81, 1990, XP002215187
SHAKLEE, PATRICK N. ET AL: "A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans", J. BIOL. CHEM. (1985), 260(16), 9146-9, 1985, XP002215188
SHAKLEE P N ET AL: "HYDRAZINOLYSIS OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 217, 1984, pages 187 - 197, XP000106697, ISSN: 0264-6021
BIENKOWSKI, MICHAEL J. ET AL: "Structural characterization of the oligosaccharides formed by depolymerization of heparin with nitrous acid", J. BIOL. CHEM. (1985), 260(1), 356-65, 1985, XP002215186
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HOPWOOD, JOHN J. ET AL: "Selective depolymerization of dermatan sulfate: production of radiolabelled substrates for.alpha.-L-iduronidase, sulfoiduronate sulfatase, and.beta.-D-glucuronidase", XP002215190, retrieved from STN Database accession no. 100:68630 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHAKLEE, PATRICK N. ET AL: "The disaccharides formed by deaminative cleavage of N-deacetylated glycosaminoglycans", XP002215191, retrieved from STN Database accession no. 105:79277 CA
EDGE, ALBERT S. B. ET AL: "Characterization of novel sequences containing 3-O-sulfated glucosamine i glomerular basement membrane heparan sulfate and localization of sulfated disaccharides to a peripheral domain", J. BIOL. CHEM. (1990), 265(26), 15874-81, 1990, XP002215187
SHAKLEE, PATRICK N. ET AL: "A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans", J. BIOL. CHEM. (1985), 260(16), 9146-9, 1985, XP002215188
SHAKLEE P N ET AL: "HYDRAZINOLYSIS OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 217, 1984, pages 187 - 197, XP000106697, ISSN: 0264-6021
Download PDF: