Title:
HYPOGLYCEMIC AGENT, LIVER PROTECTING AGENT AND ANTICANCER AGENT CONTAINING LIGNANS ORIGINATING IN HONGDOUSHAN
Document Type and Number:
WIPO Patent Application WO/2004/009065
Kind Code:
A1
Abstract:
Drugs containing taxiresinol, (7’R)-7’-hydroxylariciresinol, secoisolariciresinol and isotaxiresinol, which are lignans contained in hongdoushan, as the active ingredients. Drugs containing an extract, which is obtained by extracting a hongdoushan plant with water and further extracting the obtained extract with an organic solvent, as the active ingredient. These drugs are useful particularly as a hyopglycermic agent, a liver protecting agent and an anticancer agent.
Inventors:
KADOTA SHIGETOSHI (JP)
NOBUKAWA TAKAHIRO (JP)
NOBUKAWA TAKAHIRO (JP)
Application Number:
PCT/JP2003/009370
Publication Date:
January 29, 2004
Filing Date:
July 23, 2003
Export Citation:
Assignee:
KOTOSUGI INC (JP)
KADOTA SHIGETOSHI (JP)
NOBUKAWA TAKAHIRO (JP)
KADOTA SHIGETOSHI (JP)
NOBUKAWA TAKAHIRO (JP)
International Classes:
A61K31/085; A61K31/341; A61K36/13; A61P1/16; A61P3/10; A61P35/00; C07D307/12; (IPC1-7): A61K31/085; A61K31/341; A61K35/78; A61P1/16; A61P3/10; A61P35/00; C07D307/12
Foreign References:
| JPS6431717A | 1989-02-02 | |||
| EP0906761A2 | 1999-04-07 | |||
| US6489514B1 | 2002-12-03 | |||
| JPH09208461A | 1997-08-12 | |||
| JPH10120582A | 1998-05-12 |
Other References:
SHEN YA-CHING ET AL.: "Bioactive lignans and toxoids from the roots of formosan taxus mairei", CHINESE PHARMACEUTICAL JOURNAL, vol. 49, no. 5-6, 1997, TAIPEI, pages 285 - 296, XP002973813
CHEMICAL ABSTRACTS, vol. 121, Columbus, Ohio, US; abstract no. 292369, GUO DAIH-HUNG: "Hypoglycemic and antiplatet constituents of taxus mairei" XP002973814
MATSUDA HISASHI ET AL.: "Hepatoprotective, superoxide scavenging and antioxidative activities of armatic constitutents from the bark of Betula platyphylla", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, 1998, pages 2939 - 2944, XP004141850
CHEMICAL ABSTRACTS, vol. 46, Columbus, Ohio, US; abstract no. 9086B-I, 9087A-B, KING F.E. ET AL.: "Isotaxiresinol (3'-methylisolarciresinol), new lignan extracted from the heartwood of the England yew, taxus baccata" XP002973815
CHEMICAL ABSTRACTS, vol. 121, Columbus, Ohio, US; abstract no. 292369, GUO DAIH-HUNG: "Hypoglycemic and antiplatet constituents of taxus mairei" XP002973814
MATSUDA HISASHI ET AL.: "Hepatoprotective, superoxide scavenging and antioxidative activities of armatic constitutents from the bark of Betula platyphylla", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, 1998, pages 2939 - 2944, XP004141850
CHEMICAL ABSTRACTS, vol. 46, Columbus, Ohio, US; abstract no. 9086B-I, 9087A-B, KING F.E. ET AL.: "Isotaxiresinol (3'-methylisolarciresinol), new lignan extracted from the heartwood of the England yew, taxus baccata" XP002973815
Attorney, Agent or Firm:
Fujiwara, Michihiko (Uji-jadzuka Uji-shi, Kyoto, JP)
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