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Title:
IL-23p40 SPECIFIC IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES
Document Type and Number:
WIPO Patent Application WO2004101750
Kind Code:
A3
Abstract:
Novel anti-IL-23p40 specific human Ig derived proteins, including, without limitation, antibodies, fusion proteins, and mimetibodies, isolated nucleic acids that encode the anti-IL-23p40 Ig derived proteins, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, are useful for therapeutic compositions, methods and devices. Preferably, the anti-IL-23p40 specific human Ig derived proteins do not bind the p40 subunit of IL-12 and, thus, do not neutralize IL-12-related activity.

Inventors:
BENSON JACQUELINE (US)
CUNNINGHAM MARK (US)
Application Number:
PCT/US2004/014372
Publication Date:
December 21, 2006
Filing Date:
May 06, 2004
Export Citation:
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Assignee:
CENTOCOR INC (US)
BENSON JACQUELINE (US)
CUNNINGHAM MARK (US)
International Classes:
C12P21/08; C07H21/04; C07K16/24; C12N5/06; C12N5/16; C12P21/06; C12N
Foreign References:
US20040223969A12004-11-11
Other References:
CUA D.J. ET AL: "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.", NATURE, vol. 421, 13 February 2003 (2003-02-13), pages 744 - 748, XP002971969
See also references of EP 1623011A4
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